Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice

Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice

The circumventricular organs (CVOs) in the central nervous system (CNS) lack a vascular blood-brain barrier (BBB), creating communication sites for sensory or secretory neurons, involved in body homeostasis. Wnt/β-catenin signaling is essential for BBB development and maintenance in endothelial cell...

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Bibliographic Details
Main Authors: Fabienne Benz, Viraya Wichitnaowarat, Martin Lehmann, Raoul FV Germano, Diana Mihova, Jadranka Macas, Ralf H Adams, M Mark Taketo, Karl-Heinz Plate, Sylvaine Guérit, Benoit Vanhollebeke, Stefan Liebner
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-04-01
Series:eLife
Subjects:
circumventricular organs
subfornical organ
beta-catenin
blood-brain barrier
Wnt
water homeostasis
Online Access:https://elifesciences.org/articles/43818

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