Cysteinyl leukotriene signaling aggravates myocardial hypoxia in experimental atherosclerotic heart disease.

BACKGROUND: Cysteinyl-leukotrienes (cys-LT) are powerful spasmogenic and immune modulating lipid mediators involved in inflammatory diseases, in particular asthma. Here, we investigated whether cys-LT signaling, in the context of atherosclerotic heart disease, compromises the myocardial microcircula...

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Bibliographic Details
Main Authors: Elena Nobili, M Dolores Salvado, Lasse Folkersen, Laura Castiglioni, Jens Kastrup, Anders Wetterholm, Elena Tremoli, Göran K Hansson, Luigi Sironi, Jesper Z Haeggström, Anders Gabrielsen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3404957?pdf=render