SynthEx: a synthetic-normal-based DNA sequencing tool for copy number alteration detection and tumor heterogeneity profiling

SynthEx: a synthetic-normal-based DNA sequencing tool for copy number alteration detection and tumor heterogeneity profiling

Abstract Changes in the quantity of genetic material, known as somatic copy number alterations (CNAs), can drive tumorigenesis. Many methods exist for assessing CNAs using microarrays, but considerable technical issues limit current CNA calling based upon DNA sequencing. We present SynthEx, a novel...

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Bibliographic Details
Main Authors: Grace O. Silva, Marni B. Siegel, Lisle E. Mose, Joel S. Parker, Wei Sun, Charles M. Perou, Mengjie Chen
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Genome Biology
Subjects:
Breast cancer
Copy number
Whole exome
Sequencing
Whole genome
The Cancer Genome Atlas
Online Access:http://link.springer.com/article/10.1186/s13059-017-1193-3

Internet

http://link.springer.com/article/10.1186/s13059-017-1193-3

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