Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E

Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E

Translation of mRNA contributes to neuronal function and complex behaviours, and inflammation is thought to contribute to depression. Here the authors show that mice lacking phosphorylation sites in eIF4E (eukaryotic initiation factor 4E) display anxiety- and depression-like behaviour and decreased...

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Main Authors: Argel Aguilar-Valles, Nabila Haji, Danilo De Gregorio, Edna Matta-Camacho, Mohammad J. Eslamizade, Jelena Popic, Vijendra Sharma, Ruifeng Cao, Christoph Rummel, Arnaud Tanti, Shane Wiebe, Nicolas Nuñez, Stefano Comai, Robert Nadon, Giamal Luheshi, Naguib Mechawar, Gustavo Turecki, Jean-Claude Lacaille, Gabriella Gobbi, Nahum Sonenberg
Format: Article
Language:English
Published: Nature Publishing Group 2018-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04883-5

Internet

https://doi.org/10.1038/s41467-018-04883-5

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