Tobacco Hornworm (Manduca sexta) caterpillars as a novel host model for the study of fungal virulence and drug efficacy

Tobacco Hornworm (Manduca sexta) caterpillars as a novel host model for the study of fungal virulence and drug efficacy

The two leading yeast pathogens of humans, Candida albicans and Cryptococcus neoformans, cause systemic infections in >1.4 million patients worldwide with mortality rates approaching 75%. It is thus imperative to study fungal virulence mechanisms, efficacy of antifungal drugs, and host response p...

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Bibliographic Details
Main Authors: Naomi Lyons, Isabel Softley, Andrew Balfour, Carolyn Williamson, Heath E. O’Brien, Amol C. Shetty, Vincent M. Bruno, Stephanie Diezmann
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Virulence
Subjects:
manduca sexta
caterpillar
fungal virulence
candida
cryptococcus
saccharomyces
metschnikowia
antifungal drug
host model
fungal burden
Online Access:http://dx.doi.org/10.1080/21505594.2020.1806665

Internet

http://dx.doi.org/10.1080/21505594.2020.1806665

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