The impact of CASR A990G polymorphism in response to cinacalcet treatment in hemodialysis patients with secondary hyperparathyroidism
Abstract The objective of this study was to determine the impact of calcium sensing receptor (CASR) A990G genetic polymorphism on parathyroid hormone (PTH) lowering response to cinacalcet treatment when controlling for significant influencing clinical factors. This retrospective study was conducted...
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2021-09-01
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doaj-6ca6c890674641bb92bd0af8721a478a2021-09-12T11:25:18ZengNature Publishing GroupScientific Reports2045-23222021-09-0111111210.1038/s41598-021-97587-8The impact of CASR A990G polymorphism in response to cinacalcet treatment in hemodialysis patients with secondary hyperparathyroidismJaruwan Ngamkam0Somratai Vadcharavivad1Nutthada Areepium2Titinun Auamnoy3Kullaya Takkavatakarn4Pisut Katavetin5Khajohn Tiranathanagul6Kearkiat Praditpornsilpa7Somchai Eiam-Ong8Paweena Susantitaphong9Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn UniversityDepartment of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn UniversityDepartment of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn UniversityFaculty of Pharmaceutical Sciences, Burapha UniversityDivision of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn UniversityDivision of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn UniversityDivision of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn UniversityDivision of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn UniversityDivision of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn UniversityDivision of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn UniversityAbstract The objective of this study was to determine the impact of calcium sensing receptor (CASR) A990G genetic polymorphism on parathyroid hormone (PTH) lowering response to cinacalcet treatment when controlling for significant influencing clinical factors. This retrospective study was conducted on 135 Thai hemodialysis (HD) patients with secondary hyperparathyroidism (SHPT). CASR A990G genotypes were determined. The patients were identified as either G carriers (heterozygous or homozygous CASR 990G allele carriers) or noncarriers (homozygous CASR 990A carriers). Tested covariates were baseline PTH level (bPTH), baseline serum phosphate (bPhos), baseline serum calcium (bCa), baseline calcitriol equivalent dose (bCtriol), baseline ergocalciferol dose (bErgo), and age. The ANCOVA showed that intact PTH levels after 12 weeks of cinacalcet treatment (PTHw12) was significantly lower among G carriers compared with noncarriers after controlling for bPTH, bPhos, bCtriol, and bErgo (F(1, 127) = 15.472, p < 0.001), with the adjusted mean difference of 253.7 pg/mL. The logistic regression analysis revealed that the odds of a G carrier achieving 30% PTH reduction after 12-week cinacalcet treatment were 3.968 times greater than the odds for a noncarrier after adjusting for bPhos, bCtriol, and age. In conclusion, the CASR A990G polymorphism significantly influences cinacalcet response in HD patients with SHPT.https://doi.org/10.1038/s41598-021-97587-8 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jaruwan Ngamkam Somratai Vadcharavivad Nutthada Areepium Titinun Auamnoy Kullaya Takkavatakarn Pisut Katavetin Khajohn Tiranathanagul Kearkiat Praditpornsilpa Somchai Eiam-Ong Paweena Susantitaphong |
spellingShingle |
Jaruwan Ngamkam Somratai Vadcharavivad Nutthada Areepium Titinun Auamnoy Kullaya Takkavatakarn Pisut Katavetin Khajohn Tiranathanagul Kearkiat Praditpornsilpa Somchai Eiam-Ong Paweena Susantitaphong The impact of CASR A990G polymorphism in response to cinacalcet treatment in hemodialysis patients with secondary hyperparathyroidism Scientific Reports |
author_facet |
Jaruwan Ngamkam Somratai Vadcharavivad Nutthada Areepium Titinun Auamnoy Kullaya Takkavatakarn Pisut Katavetin Khajohn Tiranathanagul Kearkiat Praditpornsilpa Somchai Eiam-Ong Paweena Susantitaphong |
author_sort |
Jaruwan Ngamkam |
title |
The impact of CASR A990G polymorphism in response to cinacalcet treatment in hemodialysis patients with secondary hyperparathyroidism |
title_short |
The impact of CASR A990G polymorphism in response to cinacalcet treatment in hemodialysis patients with secondary hyperparathyroidism |
title_full |
The impact of CASR A990G polymorphism in response to cinacalcet treatment in hemodialysis patients with secondary hyperparathyroidism |
title_fullStr |
The impact of CASR A990G polymorphism in response to cinacalcet treatment in hemodialysis patients with secondary hyperparathyroidism |
title_full_unstemmed |
The impact of CASR A990G polymorphism in response to cinacalcet treatment in hemodialysis patients with secondary hyperparathyroidism |
title_sort |
impact of casr a990g polymorphism in response to cinacalcet treatment in hemodialysis patients with secondary hyperparathyroidism |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-09-01 |
description |
Abstract The objective of this study was to determine the impact of calcium sensing receptor (CASR) A990G genetic polymorphism on parathyroid hormone (PTH) lowering response to cinacalcet treatment when controlling for significant influencing clinical factors. This retrospective study was conducted on 135 Thai hemodialysis (HD) patients with secondary hyperparathyroidism (SHPT). CASR A990G genotypes were determined. The patients were identified as either G carriers (heterozygous or homozygous CASR 990G allele carriers) or noncarriers (homozygous CASR 990A carriers). Tested covariates were baseline PTH level (bPTH), baseline serum phosphate (bPhos), baseline serum calcium (bCa), baseline calcitriol equivalent dose (bCtriol), baseline ergocalciferol dose (bErgo), and age. The ANCOVA showed that intact PTH levels after 12 weeks of cinacalcet treatment (PTHw12) was significantly lower among G carriers compared with noncarriers after controlling for bPTH, bPhos, bCtriol, and bErgo (F(1, 127) = 15.472, p < 0.001), with the adjusted mean difference of 253.7 pg/mL. The logistic regression analysis revealed that the odds of a G carrier achieving 30% PTH reduction after 12-week cinacalcet treatment were 3.968 times greater than the odds for a noncarrier after adjusting for bPhos, bCtriol, and age. In conclusion, the CASR A990G polymorphism significantly influences cinacalcet response in HD patients with SHPT. |
url |
https://doi.org/10.1038/s41598-021-97587-8 |
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