Pharmacological Inhibition of WEE1 Potentiates the Antitumoral Effect of the <i>dl922-947</i> Oncolytic Virus in Malignant Mesothelioma Cell Lines

Pharmacological Inhibition of WEE1 Potentiates the Antitumoral Effect of the <i>dl922-947</i> Oncolytic Virus in Malignant Mesothelioma Cell Lines

Malignant mesothelioma (MM) is a very aggressive asbestos-related cancer, for which no therapy proves to be effective. We have recently shown that the oncolytic adenovirus <i>dl922-947</i> had antitumor effects in MM cell lines and murine xenografts. Previous studies demonstrated that &l...

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Bibliographic Details
Main Authors: Carmelina Antonella Iannuzzi, Paola Indovina, Iris Maria Forte, Sarah Di Somma, Anna Maria Malfitano, Martina Bruno, Giuseppe Portella, Francesca Pentimalli, Antonio Giordano
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
malignant mesothelioma
oncolytic adenovirus
<i>dl922-947</i>
WEE1
AZD1775
MK-1775
Online Access:https://www.mdpi.com/1422-0067/21/19/7333

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