Apolipoprotein-defined lipoprotein subclasses, serum apolipoproteins, and carotid intima-media thickness in T1D
Circulating apolipoprotein-defined lipoprotein subclasses (ADLS) and apolipoproteins predict vascular events in the general and type 2 diabetes populations, but data in T1D are limited. We examined associations of ADLS, serum apolipoproteins, and conventional lipids with carotid intima-media thickne...
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doaj-6cd99c0fd639430884c1020b4f5370752021-04-29T04:36:33ZengElsevierJournal of Lipid Research0022-22752018-01-01595872883Apolipoprotein-defined lipoprotein subclasses, serum apolipoproteins, and carotid intima-media thickness in T1DArpita Basu0Alicia J. Jenkins1Julie A. Stoner2Ying Zhang3Richard L. Klein4Maria F. Lopes-Virella5W.Timothy Garvey6David S. Schade7Jamie Wood8Petar Alaupovic9Timothy J. Lyons10Department of Kinesiology and Nutrition Sciences, University of Nevada Las Vegas, Las Vegas, NVNational Health and Medical Research Council Clinical Trials Centre, University of Sydney, Camperdown, Sydney, NSW, AustraliaDepartment of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OKDepartment of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OKDivision of Endocrinology, Medical University of South Carolina, Charleston, SC; The Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SCDivision of Endocrinology, Medical University of South Carolina, Charleston, SC; The Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SCDepartment of Nutrition Sciences, University of Alabama at Birmingham and the Birmingham Veterans Affairs Medical Center, Birmingham, ALDepartment of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NMDepartment of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OHOklahoma Medical Research Foundation, Oklahoma City, OKTo whom correspondence should be addressed; Division of Endocrinology, Medical University of South Carolina, Charleston, SC; To whom correspondence should be addressedCirculating apolipoprotein-defined lipoprotein subclasses (ADLS) and apolipoproteins predict vascular events in the general and type 2 diabetes populations, but data in T1D are limited. We examined associations of ADLS, serum apolipoproteins, and conventional lipids with carotid intima-media thickness (IMT) measured contemporaneously and 6 years later in 417 T1D participants [men: n = 269, age 42 ± 6 y (mean ± SD); women: n = 148, age 39 ± 8 y] in the Epidemiology of Diabetes Interventions and Complications study, the follow-up of the Diabetes Control and Complications Trial (DCCT). Date were analyzed by multiple linear regression stratified by sex, and adjusted for time-averaged hemoglobin A1C, diabetes duration, hypertension, BMI, albuminuria, DCCT randomization, smoking, statin treatment, and ultrasound devices. In cross-sectional analyses, lipoprotein B (Lp-B), Lp-B:C, Lp-B:E+Lp-B:C:E, Apo-A-II, Apo-B, Apo-C-III-HP (heparin precipitate; i.e., Apo-C-III in Apo-B-containing lipoproteins), and Apo-E were positively associated with common and/or internal carotid IMT in men, but only Apo-C-III (total) was (positively) associated with internal carotid IMT in women. In prospective analyses, Lp-B, Apo-B, and Apo-C-III-HP were positively associated with common and/or internal carotid IMT in men, while Lp-A1:AII and Apo-A1 were inversely associated with internal carotid IMT in women. The only significant prospective association between conventional lipids and IMT was between triacylglycerols and internal carotid IMT in men. ADLS and apolipoprotein concentrations may provide sex-specific biomarkers and suggest mechanisms for IMT in people with T1D.http://www.sciencedirect.com/science/article/pii/S0022227520331229Apolipoprotein BApolipoprotein-A-IApolipoprotein-C-III carotid intima-media thicknesstype 1 diabetes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Arpita Basu Alicia J. Jenkins Julie A. Stoner Ying Zhang Richard L. Klein Maria F. Lopes-Virella W.Timothy Garvey David S. Schade Jamie Wood Petar Alaupovic Timothy J. Lyons |
spellingShingle |
Arpita Basu Alicia J. Jenkins Julie A. Stoner Ying Zhang Richard L. Klein Maria F. Lopes-Virella W.Timothy Garvey David S. Schade Jamie Wood Petar Alaupovic Timothy J. Lyons Apolipoprotein-defined lipoprotein subclasses, serum apolipoproteins, and carotid intima-media thickness in T1D Journal of Lipid Research Apolipoprotein B Apolipoprotein-A-I Apolipoprotein-C-III carotid intima-media thickness type 1 diabetes |
author_facet |
Arpita Basu Alicia J. Jenkins Julie A. Stoner Ying Zhang Richard L. Klein Maria F. Lopes-Virella W.Timothy Garvey David S. Schade Jamie Wood Petar Alaupovic Timothy J. Lyons |
author_sort |
Arpita Basu |
title |
Apolipoprotein-defined lipoprotein subclasses, serum apolipoproteins, and carotid intima-media thickness in T1D |
title_short |
Apolipoprotein-defined lipoprotein subclasses, serum apolipoproteins, and carotid intima-media thickness in T1D |
title_full |
Apolipoprotein-defined lipoprotein subclasses, serum apolipoproteins, and carotid intima-media thickness in T1D |
title_fullStr |
Apolipoprotein-defined lipoprotein subclasses, serum apolipoproteins, and carotid intima-media thickness in T1D |
title_full_unstemmed |
Apolipoprotein-defined lipoprotein subclasses, serum apolipoproteins, and carotid intima-media thickness in T1D |
title_sort |
apolipoprotein-defined lipoprotein subclasses, serum apolipoproteins, and carotid intima-media thickness in t1d |
publisher |
Elsevier |
series |
Journal of Lipid Research |
issn |
0022-2275 |
publishDate |
2018-01-01 |
description |
Circulating apolipoprotein-defined lipoprotein subclasses (ADLS) and apolipoproteins predict vascular events in the general and type 2 diabetes populations, but data in T1D are limited. We examined associations of ADLS, serum apolipoproteins, and conventional lipids with carotid intima-media thickness (IMT) measured contemporaneously and 6 years later in 417 T1D participants [men: n = 269, age 42 ± 6 y (mean ± SD); women: n = 148, age 39 ± 8 y] in the Epidemiology of Diabetes Interventions and Complications study, the follow-up of the Diabetes Control and Complications Trial (DCCT). Date were analyzed by multiple linear regression stratified by sex, and adjusted for time-averaged hemoglobin A1C, diabetes duration, hypertension, BMI, albuminuria, DCCT randomization, smoking, statin treatment, and ultrasound devices. In cross-sectional analyses, lipoprotein B (Lp-B), Lp-B:C, Lp-B:E+Lp-B:C:E, Apo-A-II, Apo-B, Apo-C-III-HP (heparin precipitate; i.e., Apo-C-III in Apo-B-containing lipoproteins), and Apo-E were positively associated with common and/or internal carotid IMT in men, but only Apo-C-III (total) was (positively) associated with internal carotid IMT in women. In prospective analyses, Lp-B, Apo-B, and Apo-C-III-HP were positively associated with common and/or internal carotid IMT in men, while Lp-A1:AII and Apo-A1 were inversely associated with internal carotid IMT in women. The only significant prospective association between conventional lipids and IMT was between triacylglycerols and internal carotid IMT in men. ADLS and apolipoprotein concentrations may provide sex-specific biomarkers and suggest mechanisms for IMT in people with T1D. |
topic |
Apolipoprotein B Apolipoprotein-A-I Apolipoprotein-C-III carotid intima-media thickness type 1 diabetes |
url |
http://www.sciencedirect.com/science/article/pii/S0022227520331229 |
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