Haploinsufficiency of the autism-associated <it>Shank3 </it>gene leads to deficits in synaptic function, social interaction, and social communication

Haploinsufficiency of the autism-associated <it>Shank3 </it>gene leads to deficits in synaptic function, social interaction, and social communication

<p>Abstract</p> <p>Background</p> <p>SHANK3 is a protein in the core of the postsynaptic density (PSD) and has a critical role in recruiting many key functional elements to the PSD and to the synapse, including components of α-amino-3-hydroxyl-5-methyl-4-isoxazole-propi...

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Bibliographic Details
Main Authors: Bozdagi Ozlem, Sakurai Takeshi, Papapetrou Danae, Wang Xiaobin, Dickstein Dara L, Takahashi Nagahide, Kajiwara Yuji, Yang Mu, Katz Adam M, Scattoni Maria, Harris Mark J, Saxena Roheeni, Silverman Jill L, Crawley Jacqueline N, Zhou Qiang, Hof Patrick R, Buxbaum Joseph D
Format: Article
Language:English
Published: BMC 2010-12-01
Series:Molecular Autism
Online Access:http://www.molecularautism.com/content/1/1/15

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http://www.molecularautism.com/content/1/1/15

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