Diverging mechanisms of activation of chemokine receptors revealed by novel chemokine agonists.

Diverging mechanisms of activation of chemokine receptors revealed by novel chemokine agonists.

CXCL8/interleukin-8 is a pro-inflammatory chemokine that triggers pleiotropic responses, including inflammation, angiogenesis, wound healing and tumorigenesis. We engineered the first selective CXCR1 agonists on the basis of residue substitutions in the conserved ELR triad and CXC motif of CXCL8. Ou...

Full description

Bibliographic Details
Main Authors: Jose Sarmiento, Christie Shumate, Katsutoshi Suetomi, Aishwarya Ravindran, León Villegas, Krishna Rajarathnam, Javier Navarro
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3235101?pdf=render

Internet

http://europepmc.org/articles/PMC3235101?pdf=render

Similar Items