Pretreatment Innate Cell Populations and CD4 T Cells in Blood Are Associated With Response to Immune Checkpoint Blockade in Melanoma Patients

Pretreatment Innate Cell Populations and CD4 T Cells in Blood Are Associated With Response to Immune Checkpoint Blockade in Melanoma Patients

The development of changes in T cells, referred to as T cell exhaustion, has been suggested as a cause of primary or acquired resistance to immunotherapy by immune checkpoint blockade (ICB). A limited number of studies, largely performed on tumor infiltrating lymphocytes (TILs), has provided evidenc...

Full description

Bibliographic Details
Main Authors: Mehdi R. Pirozyan, Helen M. McGuire, Abdullah Al Emran, Hsin-Yi Tseng, Jessamy C. Tiffen, Jenny H. Lee, Matteo S. Carlino, Alexander M. Menzies, Georgina V. Long, Richard A. Scolyer, Barbara Fazekas de St Groth, Peter Hersey
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
melanoma
cancer immunotherapy
NK cells
CyTOF
T cell exhaustion
CD4 T cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00372/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00372/full

Similar Items