Ciclopirox olamine induces ferritinophagy and reduces cyst burden in polycystic kidney disease

Ciclopirox olamine induces ferritinophagy and reduces cyst burden in polycystic kidney disease

Despite the recent launch of tolvaptan, the search for safer polycystic kidney disease (PKD) drugs continues. Ciclopirox (CPX) or its olamine salt (CPX-O) is contained in a number of commercially available antifungal agents. CPX is also reported to possess anticancer activity. Several mechanisms of...

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Bibliographic Details
Main Authors: Priyanka S. Radadiya, Mackenzie M. Thornton, Rajni V. Puri, Sireesha Yerrathota, Johnny Dinh-Phan, Brenda Magenheimer, Dharmalingam Subramaniam, Pamela V. Tran, Hao Zhu, Subhashini Bolisetty, James P. Calvet, Darren P. Wallace, Madhulika Sharma
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-04-01
Series:JCI Insight
Subjects:
Nephrology
Online Access:https://doi.org/10.1172/jci.insight.141299

Internet

https://doi.org/10.1172/jci.insight.141299

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