Computational study on the allosteric mechanism of Leishmania major IF4E-1 by 4E-interacting protein-1: Unravelling the determinants of m7GTP cap recognition

Computational study on the allosteric mechanism of Leishmania major IF4E-1 by 4E-interacting protein-1: Unravelling the determinants of m7GTP cap recognition

During their life cycle, Leishmania parasites display a fine-tuned regulation of the mRNA translation through the differential expression of isoforms of eukaryotic translation initiation factor 4E (LeishIF4Es). The interaction between allosteric modulators such as 4E-interacting proteins (4E-IPs) an...

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Bibliographic Details
Main Authors: Lilian Hernández-Alvarez, Antonio B Oliveira Jr, Jorge Enrique Hernández-González, Jorge Chahine, Pedro Geraldo Pascutti, Alexandre Suman de Araujo, Fátima Pereira de Souza
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
mRNA cap
Allostery
Eukaryotic Initiation Factor-4E
4E-binding proteins
Leishmania major
Molecular dynamics
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037021001100

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http://www.sciencedirect.com/science/article/pii/S2001037021001100

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