TODRA, a lncRNA at the RAD51 Locus, Is Oppositely Regulated to RAD51, and Enhances RAD51-Dependent DSB (Double Strand Break) Repair.

TODRA, a lncRNA at the RAD51 Locus, Is Oppositely Regulated to RAD51, and Enhances RAD51-Dependent DSB (Double Strand Break) Repair.

Expression of RAD51, a crucial player in homologous recombination (HR) and DNA double-strand break (DSB) repair, is dysregulated in human tumors, and can contribute to genomic instability and tumor progression. To further understand RAD51 regulation we functionally characterized a long non-coding (l...

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Bibliographic Details
Main Authors: Inbal Gazy, David A Zeevi, Paul Renbaum, Sharon Zeligson, Lital Eini, Dana Bashari, Yoav Smith, Amnon Lahad, Michal Goldberg, Doron Ginsberg, Ephrat Levy-Lahad
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0134120

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https://doi.org/10.1371/journal.pone.0134120

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