VISTA expression associated with CD8 confers a favorable immune microenvironment and better overall survival in hepatocellular carcinoma

VISTA expression associated with CD8 confers a favorable immune microenvironment and better overall survival in hepatocellular carcinoma

Abstract Background Hepatocellular carcinoma (HCC) often arises in the setting of chronic inflammation with multiple inhibitory immune signals. V-domain Ig suppressor of T cell activation (VISTA) is identified as a novel negative checkpoint regulator. This study sought to determine the expression an...

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Bibliographic Details
Main Authors: Ming Zhang, Hua-Jin Pang, Wei Zhao, Yu-Fa Li, Li-Xu Yan, Zhong-Yi Dong, Xiao-Feng He
Format: Article
Language:English
Published: BMC 2018-05-01
Series:BMC Cancer
Subjects:
VISTA
Hepatocellular carcinoma
CD8+ tumor-infiltrating lymphocytes
Tumor microenvironment
Prognosis
Online Access:http://link.springer.com/article/10.1186/s12885-018-4435-1

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http://link.springer.com/article/10.1186/s12885-018-4435-1

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