BATF3-dependent dendritic cells drive both effector and regulatory T-cell responses in bacterially infected tissues.
The gastric lamina propria of mice that have been experimentally infected with the pathobiont Helicobacter pylori hosts a dense network of myeloid cells that includes BATF3-dependent CD103+ dendritic cells (DCs). We show here that CD103+ DCs are strictly required for gastric Th1 responses to H. pylo...
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2019-06-01
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Series: | PLoS Pathogens |
Online Access: | https://doi.org/10.1371/journal.ppat.1007866 |
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doaj-6fdcd51741634d3a96d784c5e3d7588e2021-04-21T17:10:40ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742019-06-01156e100786610.1371/journal.ppat.1007866BATF3-dependent dendritic cells drive both effector and regulatory T-cell responses in bacterially infected tissues.Isabelle C ArnoldXiaozhou ZhangMariela Artola-BoranAngela FalleggerPeter SanderPål JohansenAnne MüllerThe gastric lamina propria of mice that have been experimentally infected with the pathobiont Helicobacter pylori hosts a dense network of myeloid cells that includes BATF3-dependent CD103+ dendritic cells (DCs). We show here that CD103+ DCs are strictly required for gastric Th1 responses to H. pylori and for H. pylori infection control. A similar dependence of type 1 immunity on CD103+ DCs is observed in a Mycobacterium bovis BCG infection model, and in a syngeneic colon cancer model. Strikingly, we find that not only the expansion and/or recruitment of Th1 cells, but also of peripherally induced, neuropilin-negative regulatory T-cells to sites of infection requires BATF3-dependent DCs. A shared feature of the examined models is the strongly reduced production of the chemokines and CXCR3 ligands CXCL9, 10 and 11 in BATF3-deficient mice. The results implicate BATF3-dependent DCs in the recruitment of CXCR3+ effector and regulatory T-cells to target tissues and in their local expansion.https://doi.org/10.1371/journal.ppat.1007866 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Isabelle C Arnold Xiaozhou Zhang Mariela Artola-Boran Angela Fallegger Peter Sander Pål Johansen Anne Müller |
spellingShingle |
Isabelle C Arnold Xiaozhou Zhang Mariela Artola-Boran Angela Fallegger Peter Sander Pål Johansen Anne Müller BATF3-dependent dendritic cells drive both effector and regulatory T-cell responses in bacterially infected tissues. PLoS Pathogens |
author_facet |
Isabelle C Arnold Xiaozhou Zhang Mariela Artola-Boran Angela Fallegger Peter Sander Pål Johansen Anne Müller |
author_sort |
Isabelle C Arnold |
title |
BATF3-dependent dendritic cells drive both effector and regulatory T-cell responses in bacterially infected tissues. |
title_short |
BATF3-dependent dendritic cells drive both effector and regulatory T-cell responses in bacterially infected tissues. |
title_full |
BATF3-dependent dendritic cells drive both effector and regulatory T-cell responses in bacterially infected tissues. |
title_fullStr |
BATF3-dependent dendritic cells drive both effector and regulatory T-cell responses in bacterially infected tissues. |
title_full_unstemmed |
BATF3-dependent dendritic cells drive both effector and regulatory T-cell responses in bacterially infected tissues. |
title_sort |
batf3-dependent dendritic cells drive both effector and regulatory t-cell responses in bacterially infected tissues. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Pathogens |
issn |
1553-7366 1553-7374 |
publishDate |
2019-06-01 |
description |
The gastric lamina propria of mice that have been experimentally infected with the pathobiont Helicobacter pylori hosts a dense network of myeloid cells that includes BATF3-dependent CD103+ dendritic cells (DCs). We show here that CD103+ DCs are strictly required for gastric Th1 responses to H. pylori and for H. pylori infection control. A similar dependence of type 1 immunity on CD103+ DCs is observed in a Mycobacterium bovis BCG infection model, and in a syngeneic colon cancer model. Strikingly, we find that not only the expansion and/or recruitment of Th1 cells, but also of peripherally induced, neuropilin-negative regulatory T-cells to sites of infection requires BATF3-dependent DCs. A shared feature of the examined models is the strongly reduced production of the chemokines and CXCR3 ligands CXCL9, 10 and 11 in BATF3-deficient mice. The results implicate BATF3-dependent DCs in the recruitment of CXCR3+ effector and regulatory T-cells to target tissues and in their local expansion. |
url |
https://doi.org/10.1371/journal.ppat.1007866 |
work_keys_str_mv |
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