Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception

Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception

Cell surface reception of Sonic hedgehog (Shh) must ensure that the graded morphogenic signal is interpreted accordingly in neighboring cells to specify tissue patterns during development. Here, we report endocytic sorting signals for the receptor Patched1 (Ptch1), comprising two ‘PPXY’ motifs, that...

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Bibliographic Details
Main Authors: Shen Yue, Liu-Ya Tang, Ying Tang, Yi Tang, Qiu-Hong Shen, Jie Ding, Yan Chen, Zengdi Zhang, Ting-Ting Yu, Ying E Zhang, Steven Y Cheng
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-06-01
Series:eLife
Subjects:
sonic Hedgehog
ubiquitination
Patched
endocytosis
Smurfs
Online Access:https://elifesciences.org/articles/02555

Internet

https://elifesciences.org/articles/02555

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