Highly efficient multiplex genetic engineering of porcine primary fetal fibroblasts

Background: Genetically engineered porcine donors are a potential solution for the shortage of human organs for transplantation. Incompatibilities between humans and porcine donors are largely due to carbohydrate xenoantigens on the surface of porcine cells, provoking an immune response which leads...

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Bibliographic Details
Main Authors: Benjamin Klapholz, PhD, Heather Levy, Ramesh Kumbha, PhD, Nora Hosny, Michael E. D'Angelo, PhD, Bernhard J. Hering, MD, Christopher Burlak, PhD
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Surgery Open Science
Online Access:http://www.sciencedirect.com/science/article/pii/S2589845020300324