DDS promotes longevity through a microbiome-mediated starvation signal
The antibiotic diaminodiphenyl sulfone (DDS) is used in combination with other antibiotics as a first line treatment for leprosy. DDS has been previously reported to extend lifespan in Caenorhabditis elegans through inhibition of pyruvate kinase and decreased mitochondrial function. Here we report a...
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KeAi Communications Co., Ltd.
2019-01-01
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Series: | Translational Medicine of Aging |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2468501119300045 |
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doaj-703a38fb11dc4f9488f12d04f06a62852021-02-02T06:58:08ZengKeAi Communications Co., Ltd.Translational Medicine of Aging2468-50112019-01-0136469DDS promotes longevity through a microbiome-mediated starvation signalHaeri Choi0Sung Chun Cho1Young Wan Ha2Billie Ocampo3Shirley Park4Shiwen Chen5Christopher F. Bennett6Jeehae Han7Ryan Rossner8Jong-Sun Kang9Yun-ll Lee10Sang Chul Park11Matt Kaeberlein12Department of Obstetrics & Gynecology, Oregon Health and Science University, Portland, OR, 97239, USA; Center for Developmental Health, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR, 97239, USAWell Aging Research Center, Daegu Geongbuk Institute Science and Technology (DGIST), Daegu, 42988, South KoreaWell Aging Research Center, Samsung Advanced Institute of Technology (SAIT), Suwon, South KoreaDepartment of Pathology, University of Washington, Seattle, WA, USADepartment of Pathology, University of Washington, Seattle, WA, USADepartment of Pathology, University of Washington, Seattle, WA, USADepartment of Pathology, University of Washington, Seattle, WA, USADepartment of Pathology, University of Washington, Seattle, WA, USADepartment of Pathology, University of Washington, Seattle, WA, USADepartment of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, 16419, South Korea; Samsung Biomedical Institute, Samsung Medical Center, Seoul, 06351, South KoreaWell Aging Research Center, Daegu Geongbuk Institute Science and Technology (DGIST), Daegu, 42988, South KoreaWell Aging Research Center, Daegu Geongbuk Institute Science and Technology (DGIST), Daegu, 42988, South Korea; The Future Life and Society Research Center, Chonnam National University, Gwangju, South KoreaDepartment of Pathology, University of Washington, Seattle, WA, USA; Corresponding author.The antibiotic diaminodiphenyl sulfone (DDS) is used in combination with other antibiotics as a first line treatment for leprosy. DDS has been previously reported to extend lifespan in Caenorhabditis elegans through inhibition of pyruvate kinase and decreased mitochondrial function. Here we report an alternative mechanism of action by which DDS promotes longevity in C. elegans by reducing folate production by the microbiome. This results in altered methionine cycle metabolite levels mimicking the effects of metformin and lifespan extension that is dependent on the starvation- and hypoxia-induced flavin containing monoxygenase, FMO-2.http://www.sciencedirect.com/science/article/pii/S2468501119300045 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Haeri Choi Sung Chun Cho Young Wan Ha Billie Ocampo Shirley Park Shiwen Chen Christopher F. Bennett Jeehae Han Ryan Rossner Jong-Sun Kang Yun-ll Lee Sang Chul Park Matt Kaeberlein |
spellingShingle |
Haeri Choi Sung Chun Cho Young Wan Ha Billie Ocampo Shirley Park Shiwen Chen Christopher F. Bennett Jeehae Han Ryan Rossner Jong-Sun Kang Yun-ll Lee Sang Chul Park Matt Kaeberlein DDS promotes longevity through a microbiome-mediated starvation signal Translational Medicine of Aging |
author_facet |
Haeri Choi Sung Chun Cho Young Wan Ha Billie Ocampo Shirley Park Shiwen Chen Christopher F. Bennett Jeehae Han Ryan Rossner Jong-Sun Kang Yun-ll Lee Sang Chul Park Matt Kaeberlein |
author_sort |
Haeri Choi |
title |
DDS promotes longevity through a microbiome-mediated starvation signal |
title_short |
DDS promotes longevity through a microbiome-mediated starvation signal |
title_full |
DDS promotes longevity through a microbiome-mediated starvation signal |
title_fullStr |
DDS promotes longevity through a microbiome-mediated starvation signal |
title_full_unstemmed |
DDS promotes longevity through a microbiome-mediated starvation signal |
title_sort |
dds promotes longevity through a microbiome-mediated starvation signal |
publisher |
KeAi Communications Co., Ltd. |
series |
Translational Medicine of Aging |
issn |
2468-5011 |
publishDate |
2019-01-01 |
description |
The antibiotic diaminodiphenyl sulfone (DDS) is used in combination with other antibiotics as a first line treatment for leprosy. DDS has been previously reported to extend lifespan in Caenorhabditis elegans through inhibition of pyruvate kinase and decreased mitochondrial function. Here we report an alternative mechanism of action by which DDS promotes longevity in C. elegans by reducing folate production by the microbiome. This results in altered methionine cycle metabolite levels mimicking the effects of metformin and lifespan extension that is dependent on the starvation- and hypoxia-induced flavin containing monoxygenase, FMO-2. |
url |
http://www.sciencedirect.com/science/article/pii/S2468501119300045 |
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