Antidiabetic Activity of Vinca rosea Extracts in Alloxan-Induced Diabetic Rats

The present study was carried out to evaluate the antidiabetic activity of Vinca rosea methanolic whole plant extracts in alloxan induced diabetic rats for 14 days. The methanolic whole plant extract at high dose (500 mg/kg) exhibited significant anti-hyperglycemic activity than whole plant extract...

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Main Authors:	Mohammed Fazil Ahmed, Syed Mohammed Kazim, Syed Safiullah Ghori, Syeda Sughra Mehjabeen, Shaik Rasheed Ahmed, Shaik Mehboob Ali, Mohammed Ibrahim
Format:	Article
Language:	English
Published:	Hindawi Limited 2010-01-01
Series:	International Journal of Endocrinology
Online Access:	http://dx.doi.org/10.1155/2010/841090

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spelling	doaj-706c134ee71b4c66ab504928efb2e5382020-11-24T23:15:10ZengHindawi LimitedInternational Journal of Endocrinology1687-83371687-83452010-01-01201010.1155/2010/841090841090Antidiabetic Activity of Vinca rosea Extracts in Alloxan-Induced Diabetic RatsMohammed Fazil Ahmed0Syed Mohammed Kazim1Syed Safiullah Ghori2Syeda Sughra Mehjabeen3Shaik Rasheed Ahmed4Shaik Mehboob Ali5Mohammed Ibrahim6Department of Pharmacology and Biotechnology, Nizam Institute of Pharmacy, Deshmukhi, Pochampally (M), Near Ramoji Film City, Nalgonda 508284, Andhra Pradesh, IndiaDepartment of Pharmacology and Biotechnology, Nizam Institute of Pharmacy, Deshmukhi, Pochampally (M), Near Ramoji Film City, Nalgonda 508284, Andhra Pradesh, IndiaDepartment of Pharmacology and Biotechnology, Nizam Institute of Pharmacy, Deshmukhi, Pochampally (M), Near Ramoji Film City, Nalgonda 508284, Andhra Pradesh, IndiaDepartment of Pharmacology and Biotechnology, Nizam Institute of Pharmacy, Deshmukhi, Pochampally (M), Near Ramoji Film City, Nalgonda 508284, Andhra Pradesh, IndiaDepartment of Pharmacology and Biotechnology, Nizam Institute of Pharmacy, Deshmukhi, Pochampally (M), Near Ramoji Film City, Nalgonda 508284, Andhra Pradesh, IndiaDepartment of Microbiology, Moana Marine Biotech Ltd., Vishakapatnam 530027, Andhra Pradesh, IndiaDepartment of Pharmacology and Biotechnology, Nizam Institute of Pharmacy, Deshmukhi, Pochampally (M), Near Ramoji Film City, Nalgonda 508284, Andhra Pradesh, IndiaThe present study was carried out to evaluate the antidiabetic activity of Vinca rosea methanolic whole plant extracts in alloxan induced diabetic rats for 14 days. The methanolic whole plant extract at high dose (500 mg/kg) exhibited significant anti-hyperglycemic activity than whole plant extract at low dose (300 mg/kg) in diabetic rats. The methanolic extracts also showed improvement in parameters like body weight and lipid profile as well as regeneration of β-cells of pancreas in diabetic rats. Histopathological studies reinforce the healing of pancreas, by methanolic Vinca rosea extracts, as a possible mechanism of their antidiabetic activity.http://dx.doi.org/10.1155/2010/841090
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mohammed Fazil Ahmed Syed Mohammed Kazim Syed Safiullah Ghori Syeda Sughra Mehjabeen Shaik Rasheed Ahmed Shaik Mehboob Ali Mohammed Ibrahim
spellingShingle	Mohammed Fazil Ahmed Syed Mohammed Kazim Syed Safiullah Ghori Syeda Sughra Mehjabeen Shaik Rasheed Ahmed Shaik Mehboob Ali Mohammed Ibrahim Antidiabetic Activity of Vinca rosea Extracts in Alloxan-Induced Diabetic Rats International Journal of Endocrinology
author_facet	Mohammed Fazil Ahmed Syed Mohammed Kazim Syed Safiullah Ghori Syeda Sughra Mehjabeen Shaik Rasheed Ahmed Shaik Mehboob Ali Mohammed Ibrahim
author_sort	Mohammed Fazil Ahmed
title	Antidiabetic Activity of Vinca rosea Extracts in Alloxan-Induced Diabetic Rats
title_short	Antidiabetic Activity of Vinca rosea Extracts in Alloxan-Induced Diabetic Rats
title_full	Antidiabetic Activity of Vinca rosea Extracts in Alloxan-Induced Diabetic Rats
title_fullStr	Antidiabetic Activity of Vinca rosea Extracts in Alloxan-Induced Diabetic Rats
title_full_unstemmed	Antidiabetic Activity of Vinca rosea Extracts in Alloxan-Induced Diabetic Rats
title_sort	antidiabetic activity of vinca rosea extracts in alloxan-induced diabetic rats
publisher	Hindawi Limited
series	International Journal of Endocrinology
issn	1687-8337 1687-8345
publishDate	2010-01-01
description	The present study was carried out to evaluate the antidiabetic activity of Vinca rosea methanolic whole plant extracts in alloxan induced diabetic rats for 14 days. The methanolic whole plant extract at high dose (500 mg/kg) exhibited significant anti-hyperglycemic activity than whole plant extract at low dose (300 mg/kg) in diabetic rats. The methanolic extracts also showed improvement in parameters like body weight and lipid profile as well as regeneration of β-cells of pancreas in diabetic rats. Histopathological studies reinforce the healing of pancreas, by methanolic Vinca rosea extracts, as a possible mechanism of their antidiabetic activity.
url	http://dx.doi.org/10.1155/2010/841090
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Antidiabetic Activity of Vinca rosea Extracts in Alloxan-Induced Diabetic Rats

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