Flexible semiparametric joint modeling: an application to estimate individual lung function decline and risk of pulmonary exacerbations in cystic fibrosis

Abstract Background Epidemiologic surveillance of lung function is key to clinical care of individuals with cystic fibrosis, but lung function decline is nonlinear and often impacted by acute respiratory events known as pulmonary exacerbations. Statistical models are needed to simultaneously estimat...

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Bibliographic Details
Main Authors: Dan Li, Ruth Keogh, John P. Clancy, Rhonda D. Szczesniak
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Emerging Themes in Epidemiology
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12982-017-0067-1