SHED, PRF, and Chitosan as Three-Dimensional of Tissue Engineering for Dental Pulp Regeneration
The gold standard for pulpitis irreversible treatment is root canal treatment. However, it caused the loss of tooth vitality. To restore tooth vitality, materials that have regenerative ability in the pulp is needed. The exfoliated deciduous teeth stem cells (SHED) not only expressed specific marker...
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2021-01-01
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doaj-7108ed6316ae460cb372fab6123aff662021-03-31T05:58:50ZengWolters Kluwer Medknow PublicationsDental Hypotheses2155-82132021-01-01121434610.4103/denthyp.denthyp_121_20SHED, PRF, and Chitosan as Three-Dimensional of Tissue Engineering for Dental Pulp RegenerationKelvin Alfan Nola AnggraristaPamela Handy CeciliaAyu Anggraini Broto NagoroTania SaskiantiMeircurius Dwi Condro SurboyoThe gold standard for pulpitis irreversible treatment is root canal treatment. However, it caused the loss of tooth vitality. To restore tooth vitality, materials that have regenerative ability in the pulp is needed. The exfoliated deciduous teeth stem cells (SHED) not only expressed specific markers for mesenchymal stem cells (MSC) but also induced the odontoblastic differentiation, and stimulating the formation of endothelium and fibroblast. The combination SHED with platelet rich fibrin (PRF) and chitosan were able to facilitate and increase the migration, proliferation and odontoblastic differentiation of dental pulp cells. Based on that fact, the combination of SHED, PRF and chitosan as three-dimensional tissue engineering is promising as new modality to pulp regeneration in the clinical setting. The purpose of this review is describing the potential combination of SHED, PRF, and chitosan scaffold as three-dimensional tissue engineering for pulp regeneration.http://www.dentalhypotheses.com/article.asp?issn=2155-8213;year=2021;volume=12;issue=1;spage=43;epage=46;aulast=Anggraristachitosandental pulpprfshedtissue engineering |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kelvin Alfan Nola Anggrarista Pamela Handy Cecilia Ayu Anggraini Broto Nagoro Tania Saskianti Meircurius Dwi Condro Surboyo |
spellingShingle |
Kelvin Alfan Nola Anggrarista Pamela Handy Cecilia Ayu Anggraini Broto Nagoro Tania Saskianti Meircurius Dwi Condro Surboyo SHED, PRF, and Chitosan as Three-Dimensional of Tissue Engineering for Dental Pulp Regeneration Dental Hypotheses chitosan dental pulp prf shed tissue engineering |
author_facet |
Kelvin Alfan Nola Anggrarista Pamela Handy Cecilia Ayu Anggraini Broto Nagoro Tania Saskianti Meircurius Dwi Condro Surboyo |
author_sort |
Kelvin Alfan Nola Anggrarista |
title |
SHED, PRF, and Chitosan as Three-Dimensional of Tissue Engineering for Dental Pulp Regeneration |
title_short |
SHED, PRF, and Chitosan as Three-Dimensional of Tissue Engineering for Dental Pulp Regeneration |
title_full |
SHED, PRF, and Chitosan as Three-Dimensional of Tissue Engineering for Dental Pulp Regeneration |
title_fullStr |
SHED, PRF, and Chitosan as Three-Dimensional of Tissue Engineering for Dental Pulp Regeneration |
title_full_unstemmed |
SHED, PRF, and Chitosan as Three-Dimensional of Tissue Engineering for Dental Pulp Regeneration |
title_sort |
shed, prf, and chitosan as three-dimensional of tissue engineering for dental pulp regeneration |
publisher |
Wolters Kluwer Medknow Publications |
series |
Dental Hypotheses |
issn |
2155-8213 |
publishDate |
2021-01-01 |
description |
The gold standard for pulpitis irreversible treatment is root canal treatment. However, it caused the loss of tooth vitality. To restore tooth vitality, materials that have regenerative ability in the pulp is needed. The exfoliated deciduous teeth stem cells (SHED) not only expressed specific markers for mesenchymal stem cells (MSC) but also induced the odontoblastic differentiation, and stimulating the formation of endothelium and fibroblast. The combination SHED with platelet rich fibrin (PRF) and chitosan were able to facilitate and increase the migration, proliferation and odontoblastic differentiation of dental pulp cells. Based on that fact, the combination of SHED, PRF and chitosan as three-dimensional tissue engineering is promising as new modality to pulp regeneration in the clinical setting. The purpose of this review is describing the potential combination of SHED, PRF, and chitosan scaffold as three-dimensional tissue engineering for pulp regeneration. |
topic |
chitosan dental pulp prf shed tissue engineering |
url |
http://www.dentalhypotheses.com/article.asp?issn=2155-8213;year=2021;volume=12;issue=1;spage=43;epage=46;aulast=Anggrarista |
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