The Stereoselective Nitro-Mannich Reaction in the Synthesis of Active Pharmaceutical Ingredients and Other Biologically Active Compounds

The nitro-Mannich (aza-Henry) reaction, in which a nitroalkane and an imine react to form a β-nitroamine, is a versatile tool for target-oriented synthesis. Although the first stereoselective reaction was developed only 20 years ago, and enantioselective and diastereoselective versions for the synth...

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Bibliographic Details
Main Authors: Ana Maria Faisca Phillips, M. Fátima C. Guedes da Silva, Armando J. L. Pombeiro
Format: Article
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Chemistry
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