The Stereoselective Nitro-Mannich Reaction in the Synthesis of Active Pharmaceutical Ingredients and Other Biologically Active Compounds
The nitro-Mannich (aza-Henry) reaction, in which a nitroalkane and an imine react to form a β-nitroamine, is a versatile tool for target-oriented synthesis. Although the first stereoselective reaction was developed only 20 years ago, and enantioselective and diastereoselective versions for the synth...
Main Authors: | Ana Maria Faisca Phillips, M. Fátima C. Guedes da Silva, Armando J. L. Pombeiro |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-01-01
|
Series: | Frontiers in Chemistry |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fchem.2020.00030/full |
Similar Items
-
Stereoselective, nitro-Mannich/lactamisation cascades for the direct synthesis of heavily decorated 5-nitropiperidin-2-ones and related heterocycles
by: Pavol Jakubec, et al.
Published: (2012-04-01) -
Analysis of N-nitrosamines and nitramines in foods and herbicides
by: Hotchkiss, Joseph H.
Published: (2012) -
Formation of Bis(hydroxyalkyl)N-nitrosamines as products of the nitrosation of spermidine
by: Hotchkiss, Joseph H.
Published: (2012) -
Organocatalytic Enantioselective Henry Reactions
by: Raquel P. Herrera, et al.
Published: (2011-05-01) -
Synthesis of the reported structure of piperazirum using a nitro-Mannich reaction as the key stereochemical determining step
by: James C. Anderson, et al.
Published: (2013-08-01)