Ionizing radiation increases the endothelial permeability and the transendothelial migration of tumor cells through ADAM10-activation and subsequent degradation of VE-cadherin

Ionizing radiation increases the endothelial permeability and the transendothelial migration of tumor cells through ADAM10-activation and subsequent degradation of VE-cadherin

Abstract Background We analyzed the changes in permeability of endothelial cell layers after photon irradiation, with a focus on the metalloproteases ADAM10 and ADAM17, and on VE-cadherin, components crucial for the integrity of endothelial intercellular junctions, and their roles in the transmigrat...

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Bibliographic Details
Main Authors: Pascaline Nguemgo Kouam, Günther A. Rezniczek, Irenäus A. Adamietz, Helmut Bühler
Format: Article
Language:English
Published: BMC 2019-10-01
Series:BMC Cancer
Subjects:
Irradiation
Endothelium
VE-cadherin
Metalloproteinase
Permeability
Online Access:http://link.springer.com/article/10.1186/s12885-019-6219-7

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http://link.springer.com/article/10.1186/s12885-019-6219-7

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