Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis.

Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis.

Levels of certain circulating short-chain dicarboxylacylcarnitine (SCDA), long-chain dicarboxylacylcarnitine (LCDA) and medium chain acylcarnitine (MCA) metabolites are heritable and predict cardiovascular disease (CVD) events. Little is known about the biological pathways that influence levels of m...

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Bibliographic Details
Main Authors: William E Kraus, Deborah M Muoio, Robert Stevens, Damian Craig, James R Bain, Elizabeth Grass, Carol Haynes, Lydia Kwee, Xuejun Qin, Dorothy H Slentz, Deidre Krupp, Michael Muehlbauer, Elizabeth R Hauser, Simon G Gregory, Christopher B Newgard, Svati H Shah
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-11-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4634848?pdf=render

Internet

http://europepmc.org/articles/PMC4634848?pdf=render

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