Tumor cell endogenous HIF-1α activity induces aberrant angiogenesis and interacts with TRAF6 pathway required for colorectal cancer development

Tumor cell endogenous HIF-1α activity induces aberrant angiogenesis and interacts with TRAF6 pathway required for colorectal cancer development

Hypoxia and inflammation are key factors for colorectal cancer tumorigenesis. The colonic epithelium belongs to the tissues with the lowest partial pressure of oxygen in the body, and chronic inflammation is associated with an increased chance to develop colon cancer. How the colonic epithelium resp...

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Bibliographic Details
Main Authors: Jesus F. Glaus Garzon, Chiara Pastrello, Igor Jurisica, Michael O. Hottiger, Roland H. Wenger, Lubor Borsig
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Colorectal cancer
Tumorigenesis
Tumor hypoxia
HIF-1α
Inflammation
TRAF6
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558620301615

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http://www.sciencedirect.com/science/article/pii/S1476558620301615

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