LGR5 marks targetable tumor-initiating cells in mouse liver cancer

LGR5 marks targetable tumor-initiating cells in mouse liver cancer

Cancer stem cells (CSCs) are thought to be the main drivers for disease progression and treatment resistance in liver cancer. This study identifies the LGR5+ compartment as an important CSC population, representing a viable therapeutic target for combating liver cancer.

Bibliographic Details
Main Authors: Wanlu Cao, Meng Li, Jiaye Liu, Shaoshi Zhang, Lisanne Noordam, Monique M. A. Verstegen, Ling Wang, Buyun Ma, Shan Li, Wenshi Wang, Michiel Bolkestein, Michael Doukas, Kan Chen, Zhongren Ma, Marco Bruno, Dave Sprengers, Jaap Kwekkeboom, Luc J. W. van der Laan, Ron Smits, Maikel P. Peppelenbosch, Qiuwei Pan
Format: Article
Language:English
Published: Nature Publishing Group 2020-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15846-0

Internet

https://doi.org/10.1038/s41467-020-15846-0

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