LGR5 marks targetable tumor-initiating cells in mouse liver cancer
Cancer stem cells (CSCs) are thought to be the main drivers for disease progression and treatment resistance in liver cancer. This study identifies the LGR5+ compartment as an important CSC population, representing a viable therapeutic target for combating liver cancer.
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| Language: | English |
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Nature Publishing Group
2020-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-15846-0 |
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doaj-71ee0de1c34f4f6fa934afafed4f5a27 |
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doaj-71ee0de1c34f4f6fa934afafed4f5a272021-05-11T08:00:40ZengNature Publishing GroupNature Communications2041-17232020-04-0111111610.1038/s41467-020-15846-0LGR5 marks targetable tumor-initiating cells in mouse liver cancerWanlu Cao0Meng Li1Jiaye Liu2Shaoshi Zhang3Lisanne Noordam4Monique M. A. Verstegen5Ling Wang6Buyun Ma7Shan Li8Wenshi Wang9Michiel Bolkestein10Michael Doukas11Kan Chen12Zhongren Ma13Marco Bruno14Dave Sprengers15Jaap Kwekkeboom16Luc J. W. van der Laan17Ron Smits18Maikel P. Peppelenbosch19Qiuwei Pan20Department of Gastroenterology and Hepatology, Erasmus MC-University Medical CenterDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical CenterDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical CenterDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical CenterDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical CenterDepartment of Surgery, Erasmus MC-University Medical CenterDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical CenterDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical CenterDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical CenterDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical CenterDepartment of Surgery, Erasmus MC-University Medical CenterDepartment of Pathology, Erasmus MC-University Medical CenterDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical CenterBiomedical Research Center, Northwest Minzu UniversityDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical CenterDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical CenterDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical CenterDepartment of Surgery, Erasmus MC-University Medical CenterDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical CenterDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical CenterDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical CenterCancer stem cells (CSCs) are thought to be the main drivers for disease progression and treatment resistance in liver cancer. This study identifies the LGR5+ compartment as an important CSC population, representing a viable therapeutic target for combating liver cancer.https://doi.org/10.1038/s41467-020-15846-0 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Wanlu Cao Meng Li Jiaye Liu Shaoshi Zhang Lisanne Noordam Monique M. A. Verstegen Ling Wang Buyun Ma Shan Li Wenshi Wang Michiel Bolkestein Michael Doukas Kan Chen Zhongren Ma Marco Bruno Dave Sprengers Jaap Kwekkeboom Luc J. W. van der Laan Ron Smits Maikel P. Peppelenbosch Qiuwei Pan |
| spellingShingle |
Wanlu Cao Meng Li Jiaye Liu Shaoshi Zhang Lisanne Noordam Monique M. A. Verstegen Ling Wang Buyun Ma Shan Li Wenshi Wang Michiel Bolkestein Michael Doukas Kan Chen Zhongren Ma Marco Bruno Dave Sprengers Jaap Kwekkeboom Luc J. W. van der Laan Ron Smits Maikel P. Peppelenbosch Qiuwei Pan LGR5 marks targetable tumor-initiating cells in mouse liver cancer Nature Communications |
| author_facet |
Wanlu Cao Meng Li Jiaye Liu Shaoshi Zhang Lisanne Noordam Monique M. A. Verstegen Ling Wang Buyun Ma Shan Li Wenshi Wang Michiel Bolkestein Michael Doukas Kan Chen Zhongren Ma Marco Bruno Dave Sprengers Jaap Kwekkeboom Luc J. W. van der Laan Ron Smits Maikel P. Peppelenbosch Qiuwei Pan |
| author_sort |
Wanlu Cao |
| title |
LGR5 marks targetable tumor-initiating cells in mouse liver cancer |
| title_short |
LGR5 marks targetable tumor-initiating cells in mouse liver cancer |
| title_full |
LGR5 marks targetable tumor-initiating cells in mouse liver cancer |
| title_fullStr |
LGR5 marks targetable tumor-initiating cells in mouse liver cancer |
| title_full_unstemmed |
LGR5 marks targetable tumor-initiating cells in mouse liver cancer |
| title_sort |
lgr5 marks targetable tumor-initiating cells in mouse liver cancer |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-04-01 |
| description |
Cancer stem cells (CSCs) are thought to be the main drivers for disease progression and treatment resistance in liver cancer. This study identifies the LGR5+ compartment as an important CSC population, representing a viable therapeutic target for combating liver cancer. |
| url |
https://doi.org/10.1038/s41467-020-15846-0 |
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