Possible giant cell arteritis symptoms are common in newly diagnosed patients with Polymyalgia Rheumatica: results from an incident primary care PMR cohort
Abstract Background To examine the frequency of possible giant cell arteritis (GCA) symptoms (including headache, temporal/scalp tenderness, jaw claudication and visual symptoms) in newly diagnosed polymyalgia rheumatica (PMR) patients in UK primary care. Methods The PMR Cohort Study is a primary ca...
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doaj-72303b80953246649a2f9b9ed856fc332020-11-25T02:32:04ZengBMCBMC Rheumatology2520-10262017-12-01111510.1186/s41927-017-0007-2Possible giant cell arteritis symptoms are common in newly diagnosed patients with Polymyalgia Rheumatica: results from an incident primary care PMR cohortWilliam Masson0Sara Muller1Rebecca Whittle2James Prior3Toby Helliwell4Christian Mallen5Samantha L. Hider6Arthritis Research UK Primary Care Centre, Primary Care Sciences, Keele UniversityArthritis Research UK Primary Care Centre, Primary Care Sciences, Keele UniversityArthritis Research UK Primary Care Centre, Primary Care Sciences, Keele UniversityArthritis Research UK Primary Care Centre, Primary Care Sciences, Keele UniversityArthritis Research UK Primary Care Centre, Primary Care Sciences, Keele UniversityArthritis Research UK Primary Care Centre, Primary Care Sciences, Keele UniversityArthritis Research UK Primary Care Centre, Primary Care Sciences, Keele UniversityAbstract Background To examine the frequency of possible giant cell arteritis (GCA) symptoms (including headache, temporal/scalp tenderness, jaw claudication and visual symptoms) in newly diagnosed polymyalgia rheumatica (PMR) patients in UK primary care. Methods The PMR Cohort Study is a primary care inception cohort of 652 adults with newly diagnosed polymyalgia rheumatica (PMR). At baseline, participants were asked to report (yes/no) on the presence of seven potential GCA symptoms: sudden headache, tender scalp, disturbed/double vision, jaw claudication, fever, appetite loss and unintentional weight loss. Results Of the 652 patients, 405 (62%) were female, with a mean (SD) age of 72.5 (8.9) years. Sudden headache was the commonest symptom in 161 patients (24.7%). The least commonly reported symptom was jaw claudication in 66 (10.1%) patients. Females had a higher prevalence of headache, tender scalp and jaw pain. Sudden onset headache and fever were commoner in younger patients, (OR (95% CI) per 10 year age band increase: headache 0.76 (0.62–0.92), fever 0.63 (0.49, 0.79)). In those reporting sudden headache (n = 161), 19.9% (n = 32) also reported double/disturbed vision and a tender scalp, whilst 11.8% (n = 19) reported double/disturbed vision and jaw pain. Conclusion The data suggests possible GCA symptoms are common in PMR patients, particularly sudden headache, appetite loss and weight loss. These symptomatic PMR patients warrant careful monitoring and consideration for early referral to specialist services.http://link.springer.com/article/10.1186/s41927-017-0007-2Polymyalgia rheumaticaGiant cell arteritisHeadache |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
William Masson Sara Muller Rebecca Whittle James Prior Toby Helliwell Christian Mallen Samantha L. Hider |
spellingShingle |
William Masson Sara Muller Rebecca Whittle James Prior Toby Helliwell Christian Mallen Samantha L. Hider Possible giant cell arteritis symptoms are common in newly diagnosed patients with Polymyalgia Rheumatica: results from an incident primary care PMR cohort BMC Rheumatology Polymyalgia rheumatica Giant cell arteritis Headache |
author_facet |
William Masson Sara Muller Rebecca Whittle James Prior Toby Helliwell Christian Mallen Samantha L. Hider |
author_sort |
William Masson |
title |
Possible giant cell arteritis symptoms are common in newly diagnosed patients with Polymyalgia Rheumatica: results from an incident primary care PMR cohort |
title_short |
Possible giant cell arteritis symptoms are common in newly diagnosed patients with Polymyalgia Rheumatica: results from an incident primary care PMR cohort |
title_full |
Possible giant cell arteritis symptoms are common in newly diagnosed patients with Polymyalgia Rheumatica: results from an incident primary care PMR cohort |
title_fullStr |
Possible giant cell arteritis symptoms are common in newly diagnosed patients with Polymyalgia Rheumatica: results from an incident primary care PMR cohort |
title_full_unstemmed |
Possible giant cell arteritis symptoms are common in newly diagnosed patients with Polymyalgia Rheumatica: results from an incident primary care PMR cohort |
title_sort |
possible giant cell arteritis symptoms are common in newly diagnosed patients with polymyalgia rheumatica: results from an incident primary care pmr cohort |
publisher |
BMC |
series |
BMC Rheumatology |
issn |
2520-1026 |
publishDate |
2017-12-01 |
description |
Abstract Background To examine the frequency of possible giant cell arteritis (GCA) symptoms (including headache, temporal/scalp tenderness, jaw claudication and visual symptoms) in newly diagnosed polymyalgia rheumatica (PMR) patients in UK primary care. Methods The PMR Cohort Study is a primary care inception cohort of 652 adults with newly diagnosed polymyalgia rheumatica (PMR). At baseline, participants were asked to report (yes/no) on the presence of seven potential GCA symptoms: sudden headache, tender scalp, disturbed/double vision, jaw claudication, fever, appetite loss and unintentional weight loss. Results Of the 652 patients, 405 (62%) were female, with a mean (SD) age of 72.5 (8.9) years. Sudden headache was the commonest symptom in 161 patients (24.7%). The least commonly reported symptom was jaw claudication in 66 (10.1%) patients. Females had a higher prevalence of headache, tender scalp and jaw pain. Sudden onset headache and fever were commoner in younger patients, (OR (95% CI) per 10 year age band increase: headache 0.76 (0.62–0.92), fever 0.63 (0.49, 0.79)). In those reporting sudden headache (n = 161), 19.9% (n = 32) also reported double/disturbed vision and a tender scalp, whilst 11.8% (n = 19) reported double/disturbed vision and jaw pain. Conclusion The data suggests possible GCA symptoms are common in PMR patients, particularly sudden headache, appetite loss and weight loss. These symptomatic PMR patients warrant careful monitoring and consideration for early referral to specialist services. |
topic |
Polymyalgia rheumatica Giant cell arteritis Headache |
url |
http://link.springer.com/article/10.1186/s41927-017-0007-2 |
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