A Molecular Biophysical Approach to Diclofenac Topical Gastrointestinal Damage

A Molecular Biophysical Approach to Diclofenac Topical Gastrointestinal Damage

Diclofenac (DCF), the most widely consumed non-steroidal anti-inflammatory drug (NSAID) worldwide, is associated with adverse typical effects, including gastrointestinal (GI) complications. The present study aims to better understand the topical toxicity induced by DCF using membrane models that mim...

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Bibliographic Details
Main Authors: Eduarda Fernandes, Telma B. Soares, Hugo Gonçalves, Sigrid Bernstorff, Maria Elisabete C. D. Real Oliveira, Carla M. Lopes, Marlene Lúcio
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:International Journal of Molecular Sciences
Subjects:
diclofenac
NSAIDs
derivative spectrophotometry
steady-state and time-resolved fluorescence
steady-state anisotropy
DLS
DSC
SAXS
WAXS
gastrointestinal topical toxicity
Online Access:https://www.mdpi.com/1422-0067/19/11/3411

Internet

https://www.mdpi.com/1422-0067/19/11/3411

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