Efficacy of ultrasonography and Tc-99m MIBI SPECT/CT in preoperative localization of parathyroid adenomas causing primary hyperthyroidism
Abstract Background Primary hyperparathyroidism (PHPT) results from an excess of parathyroid hormone (PTH) produced from an overactive parathyroid gland. The study aimed to explore the sonographic features of parathyroid adenomas and assess the diagnostic performance of ultrasonography (US) and Tc-9...
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doaj-72ac4f14879b42a7a962a034a9d0c4682021-05-23T11:43:27ZengBMCBMC Medical Imaging1471-23422021-05-012111910.1186/s12880-021-00616-1Efficacy of ultrasonography and Tc-99m MIBI SPECT/CT in preoperative localization of parathyroid adenomas causing primary hyperthyroidismRuigang Lu0Wei Zhao1Li Yin2Ruijun Guo3Bojun Wei4Mulan Jin5Xiang Zhou6Chun Zhang7Xiuzhang Lv8Department of Ultrasound, Beijing Chaoyang Hospital, Capital Medical UniversityDepartment of Ultrasound, Beijing Chaoyang Hospital, Capital Medical UniversityDepartment of Ultrasound, Beijing Chaoyang Hospital, Capital Medical UniversityDepartment of Ultrasound, Beijing Chaoyang Hospital, Capital Medical UniversityDepartment of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical UniversityDepartment of Pathology, Beijing Chaoyang Hospital, Capital Medical UniversityDepartment of Pathology, Beijing Chaoyang Hospital, Capital Medical UniversityDepartment of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical UniversityDepartment of Echocardiography, Beijing Chaoyang Hospital, Capital Medical UniversityAbstract Background Primary hyperparathyroidism (PHPT) results from an excess of parathyroid hormone (PTH) produced from an overactive parathyroid gland. The study aimed to explore the sonographic features of parathyroid adenomas and assess the diagnostic performance of ultrasonography (US) and Tc-99m MIBI SPECT/CT for preoperative localization of parathyroid adenomas. Methods A total of 107 patients were enrolled in this retrospective study who had PHPT and underwent parathyroidectomy. Of the 107 patients, 97 performed US and Tc-99m MIBI SPECT/CT examinations for preoperative localization of parathyroid nodules. The sensitivity and accuracy of each modality were calculated. Results In this study, residual parathyroid sign and polar vascular sign were identified as characteristic US features of parathyroid adenomas. These manifestations were closely related to the size of the abnormal parathyroid lesions. Among the 108 parathyroid nodules from 97 patients with PHPT, the sensitivity and accuracy of US for locating the parathyroid nodules were significantly higher than those of Tc-99m MIBI SPECT/CT (93.0% vs. 63.0% and 88.0% vs. 63.0% respectively; χ2 = 26.224, 18.227 respectively, P < 0.001). The differences between US + Tc-99m MIBI SPECT/CT and Tc-99m MIBI SPECT/CT-alone were statistically significant (χ2 = 33.410, 21.587 respectively, P < 0.001), yet there were no significant differences in the sensitivity or accuracy between US + Tc-99m MIBI SPECT/CT and US-alone (χ2 = 0.866, 0.187 respectively, P = 0.352 and 0.665). Conclusions US shows significantly better sensitivity and accuracy for localization of parathyroid adenomas than Tc-99m MIBI SPECT/CT. However, US combined with Tc-99m MIBI SPECT/CT is of great clinical value in the preoperative localization of parathyroid nodules in patients with PHPT.https://doi.org/10.1186/s12880-021-00616-1UltrasonographyTc-99m MIBI SPECT/CTPrimary hyperparathyroidismParathyroid adenoma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ruigang Lu Wei Zhao Li Yin Ruijun Guo Bojun Wei Mulan Jin Xiang Zhou Chun Zhang Xiuzhang Lv |
spellingShingle |
Ruigang Lu Wei Zhao Li Yin Ruijun Guo Bojun Wei Mulan Jin Xiang Zhou Chun Zhang Xiuzhang Lv Efficacy of ultrasonography and Tc-99m MIBI SPECT/CT in preoperative localization of parathyroid adenomas causing primary hyperthyroidism BMC Medical Imaging Ultrasonography Tc-99m MIBI SPECT/CT Primary hyperparathyroidism Parathyroid adenoma |
author_facet |
Ruigang Lu Wei Zhao Li Yin Ruijun Guo Bojun Wei Mulan Jin Xiang Zhou Chun Zhang Xiuzhang Lv |
author_sort |
Ruigang Lu |
title |
Efficacy of ultrasonography and Tc-99m MIBI SPECT/CT in preoperative localization of parathyroid adenomas causing primary hyperthyroidism |
title_short |
Efficacy of ultrasonography and Tc-99m MIBI SPECT/CT in preoperative localization of parathyroid adenomas causing primary hyperthyroidism |
title_full |
Efficacy of ultrasonography and Tc-99m MIBI SPECT/CT in preoperative localization of parathyroid adenomas causing primary hyperthyroidism |
title_fullStr |
Efficacy of ultrasonography and Tc-99m MIBI SPECT/CT in preoperative localization of parathyroid adenomas causing primary hyperthyroidism |
title_full_unstemmed |
Efficacy of ultrasonography and Tc-99m MIBI SPECT/CT in preoperative localization of parathyroid adenomas causing primary hyperthyroidism |
title_sort |
efficacy of ultrasonography and tc-99m mibi spect/ct in preoperative localization of parathyroid adenomas causing primary hyperthyroidism |
publisher |
BMC |
series |
BMC Medical Imaging |
issn |
1471-2342 |
publishDate |
2021-05-01 |
description |
Abstract Background Primary hyperparathyroidism (PHPT) results from an excess of parathyroid hormone (PTH) produced from an overactive parathyroid gland. The study aimed to explore the sonographic features of parathyroid adenomas and assess the diagnostic performance of ultrasonography (US) and Tc-99m MIBI SPECT/CT for preoperative localization of parathyroid adenomas. Methods A total of 107 patients were enrolled in this retrospective study who had PHPT and underwent parathyroidectomy. Of the 107 patients, 97 performed US and Tc-99m MIBI SPECT/CT examinations for preoperative localization of parathyroid nodules. The sensitivity and accuracy of each modality were calculated. Results In this study, residual parathyroid sign and polar vascular sign were identified as characteristic US features of parathyroid adenomas. These manifestations were closely related to the size of the abnormal parathyroid lesions. Among the 108 parathyroid nodules from 97 patients with PHPT, the sensitivity and accuracy of US for locating the parathyroid nodules were significantly higher than those of Tc-99m MIBI SPECT/CT (93.0% vs. 63.0% and 88.0% vs. 63.0% respectively; χ2 = 26.224, 18.227 respectively, P < 0.001). The differences between US + Tc-99m MIBI SPECT/CT and Tc-99m MIBI SPECT/CT-alone were statistically significant (χ2 = 33.410, 21.587 respectively, P < 0.001), yet there were no significant differences in the sensitivity or accuracy between US + Tc-99m MIBI SPECT/CT and US-alone (χ2 = 0.866, 0.187 respectively, P = 0.352 and 0.665). Conclusions US shows significantly better sensitivity and accuracy for localization of parathyroid adenomas than Tc-99m MIBI SPECT/CT. However, US combined with Tc-99m MIBI SPECT/CT is of great clinical value in the preoperative localization of parathyroid nodules in patients with PHPT. |
topic |
Ultrasonography Tc-99m MIBI SPECT/CT Primary hyperparathyroidism Parathyroid adenoma |
url |
https://doi.org/10.1186/s12880-021-00616-1 |
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