Low-Frequency NNRTI-Resistant HIV-1 Variants and Relationship to Mutational Load in Antiretroviral-Naïve Subjects

Low-Frequency NNRTI-Resistant HIV-1 Variants and Relationship to Mutational Load in Antiretroviral-Naïve Subjects

Low-frequency HIV variants possessing resistance mutations against non‑nucleoside reverse transcriptase inhibitors (NNRTI), especially at HIV reverse transcriptase (RT) amino acid (aa) positions K103 and Y181, have been shown to adversely affect treatment response. Therapeutic failure correlates wit...

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Bibliographic Details
Main Authors: Shaili Gupta, Max Lataillade, Tassos C. Kyriakides, Jennifer Chiarella, Elizabeth P. St. John, Suzin Webb, Elizabeth A. Moreno, Birgitte B. Simen, Michael J. Kozal
Format: Article
Language:English
Published: MDPI AG 2014-09-01
Series:Viruses
Subjects:
NNRTI
non-nucleoside reverse transcriptase inhibitors
HIV
resistance
NNRTI resistance mutations
low frequency variants
mutational load
mutant variant frequency
Online Access:http://www.mdpi.com/1999-4915/6/9/3428

Internet

http://www.mdpi.com/1999-4915/6/9/3428

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