Knockdown of UTX/KDM6A Enriches Precursor Cell Populations in Urothelial Cell Cultures and Cell Lines

The histone demethylase UTX (gene: <i>KDM6A</i>) directs cell and tissue differentiation during development. Deleterious mutations in <i>KDM6A</i> occur in many human cancers, most frequently in urothelial carcinoma. The consequences of these mutations are poorly understood;...

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Bibliographic Details
Main Authors: Alexander Lang, Patcharawalai Whongsiri, Merve Yilmaz, Tobias Lautwein, Patrick Petzsch, Annemarie Greife, Cagatay Günes, Karl Köhrer, Günter Niegisch, Michèle Hoffmann, Wolfgang A. Schulz
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
Online Access:https://www.mdpi.com/2072-6694/12/4/1023