Down-regulation of miR-101 in endothelial cells promotes blood vessel formation through reduced repression of EZH2.

Down-regulation of miR-101 in endothelial cells promotes blood vessel formation through reduced repression of EZH2.

Angiogenesis is a balanced process controlled by pro- and anti-angiogenic molecules of which the regulation is not fully understood. Besides classical gene regulation, miRNAs have emerged as post-transcriptional regulators of angiogenesis. Furthermore, epigenetic changes caused by histone-modifying...

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Main Authors: Michiel Smits, Shahryar E Mir, R Jonas A Nilsson, Petra M van der Stoop, Johanna M Niers, Victor E Marquez, Jacqueline Cloos, Xandra O Breakefield, Anna M Krichevsky, David P Noske, Bakhos A Tannous, Thomas Würdinger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3030563?pdf=render

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