Use of Proteomics in the Study of Mastitis in Ewes

The objective of this review is to describe the usage and applicability of proteomics technologies in the study of mastitis in ewes. In ewes, proteomics technologies have been employed for furthering knowledge in mastitis caused by various agents (<i>Staphylococcus aureus</i>, <i>S...

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Main Authors: Angeliki I. Katsafadou, Natalia G. C. Vasileiou, George C. Fthenakis
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Pathogens
Subjects:
Online Access:https://www.mdpi.com/2076-0817/8/3/134
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spelling doaj-73c9ea5e45824ab1be9344469f9f874b2020-11-25T01:31:31ZengMDPI AGPathogens2076-08172019-08-018313410.3390/pathogens8030134pathogens8030134Use of Proteomics in the Study of Mastitis in EwesAngeliki I. Katsafadou0Natalia G. C. Vasileiou1George C. Fthenakis2Veterinary Faculty, University of Thessaly, 43100 Karditsa, GreeceVeterinary Faculty, University of Thessaly, 43100 Karditsa, GreeceVeterinary Faculty, University of Thessaly, 43100 Karditsa, GreeceThe objective of this review is to describe the usage and applicability of proteomics technologies in the study of mastitis in ewes. In ewes, proteomics technologies have been employed for furthering knowledge in mastitis caused by various agents (<i>Staphylococcus aureus</i>, <i>Staphylococcus chromogenes</i>, <i>Mannheimia haemolytica</i>, <i>Streptococcus uberis</i>, <i>Mycoplasma agalactiae</i>). Studies have focused on improving knowledge regarding pathogenesis of the infections and identifying biomarkers for its diagnosis. Findings have revealed that ewes with mastitis mount a defence response, controlled by many proteins and over various mechanisms and pathways, which are interdependent at various points. Many proteins can participate in this process. Moreover, as the result of proteomics studies, cathelicidins and serum amyloid A have been identified as proteins that can be used as biomarkers for improved diagnosis of the disease. In the long term, proteomics will contribute to improvements in the elucidation of the pathogenesis of mastitis. Further in-depth investigations into the various proteomes and application of new methodological strategies in experimental and clinical studies will provide information about mastitis processes, which will be of benefit in controlling the disease. Improvement of diagnostic techniques, establishment of prognostic tools and development of vaccines are key areas for targeted research.https://www.mdpi.com/2076-0817/8/3/134cathelicidindiagnosispathogenesismastitissheepsubclinical mastitis
collection DOAJ
language English
format Article
sources DOAJ
author Angeliki I. Katsafadou
Natalia G. C. Vasileiou
George C. Fthenakis
spellingShingle Angeliki I. Katsafadou
Natalia G. C. Vasileiou
George C. Fthenakis
Use of Proteomics in the Study of Mastitis in Ewes
Pathogens
cathelicidin
diagnosis
pathogenesis
mastitis
sheep
subclinical mastitis
author_facet Angeliki I. Katsafadou
Natalia G. C. Vasileiou
George C. Fthenakis
author_sort Angeliki I. Katsafadou
title Use of Proteomics in the Study of Mastitis in Ewes
title_short Use of Proteomics in the Study of Mastitis in Ewes
title_full Use of Proteomics in the Study of Mastitis in Ewes
title_fullStr Use of Proteomics in the Study of Mastitis in Ewes
title_full_unstemmed Use of Proteomics in the Study of Mastitis in Ewes
title_sort use of proteomics in the study of mastitis in ewes
publisher MDPI AG
series Pathogens
issn 2076-0817
publishDate 2019-08-01
description The objective of this review is to describe the usage and applicability of proteomics technologies in the study of mastitis in ewes. In ewes, proteomics technologies have been employed for furthering knowledge in mastitis caused by various agents (<i>Staphylococcus aureus</i>, <i>Staphylococcus chromogenes</i>, <i>Mannheimia haemolytica</i>, <i>Streptococcus uberis</i>, <i>Mycoplasma agalactiae</i>). Studies have focused on improving knowledge regarding pathogenesis of the infections and identifying biomarkers for its diagnosis. Findings have revealed that ewes with mastitis mount a defence response, controlled by many proteins and over various mechanisms and pathways, which are interdependent at various points. Many proteins can participate in this process. Moreover, as the result of proteomics studies, cathelicidins and serum amyloid A have been identified as proteins that can be used as biomarkers for improved diagnosis of the disease. In the long term, proteomics will contribute to improvements in the elucidation of the pathogenesis of mastitis. Further in-depth investigations into the various proteomes and application of new methodological strategies in experimental and clinical studies will provide information about mastitis processes, which will be of benefit in controlling the disease. Improvement of diagnostic techniques, establishment of prognostic tools and development of vaccines are key areas for targeted research.
topic cathelicidin
diagnosis
pathogenesis
mastitis
sheep
subclinical mastitis
url https://www.mdpi.com/2076-0817/8/3/134
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AT nataliagcvasileiou useofproteomicsinthestudyofmastitisinewes
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