PAR2 Deficiency Induces Mitochondrial ROS Generation and Dysfunctions, Leading to the Inhibition of Adipocyte Differentiation

Protease-activated receptor 2 (PAR2) is a member of G-protein-coupled receptors and affects ligand-modulated calcium signaling. Although PAR2 signaling promotes obesity and adipose tissue inflammation in high fat- (HF-) fed conditions, its role in adipocyte differentiation under nonobesogenic condit...

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Bibliographic Details
Main Authors: Yeo Jin Park, Bonggi Lee, Dae Hyun Kim, Eun-Bin Kwon, Younghoon Go, Sugyeong Ha, Min-Kyeong Lee, Hak Sun Yu, Hae Young Chung
Format: Article
Language:English
Published: Hindawi Limited 2021-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2021/6683033