Carbetocin in prevention of postpartum hemorrhage: Experience in a tertiary medical center of Taiwan
Objective: The aim of this retrospective observational study was to determine the efficacy of carbetocin in reducing blood loss and primary postpartum hemorrhage (PPH) in vaginal and cesarean deliveries in a tertiary hospital in Taiwan. Materials and methods: Eligible gravid women (27–41 weeks) with...
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doaj-74330ab5269841d2973c7993103e0ccc2020-11-24T20:49:17ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592016-12-0155680480910.1016/j.tjog.2016.07.009Carbetocin in prevention of postpartum hemorrhage: Experience in a tertiary medical center of TaiwanChih-Yao Chen0Yi-Ning Su1Tzu-Hung Lin2Yi Chang3Huann-Cheng Horng4Peng-Hui Wang5Chang-Ching Yeh6Wen-Hsun Chang7Hsin-Yi Huang8Dianthus MFM Center Minquan, Dianthus MFM Group, Taipei, TaiwanDianthus MFM Center Minquan, Dianthus MFM Group, Taipei, TaiwanDianthus MFM Center Minquan, Dianthus MFM Group, Taipei, TaiwanDepartment of Obstetrics and Gynecology, National Yang-Ming University, Taipei, TaiwanDepartment of Obstetrics and Gynecology, National Yang-Ming University, Taipei, TaiwanDepartment of Obstetrics and Gynecology, National Yang-Ming University, Taipei, TaiwanDepartment of Obstetrics and Gynecology, National Yang-Ming University, Taipei, TaiwanDepartment of Nursing, Taipei Veterans General Hospital, Taipei, TaiwanBiostatics Task Force, Taipei Veterans General Hospital, Taipei, TaiwanObjective: The aim of this retrospective observational study was to determine the efficacy of carbetocin in reducing blood loss and primary postpartum hemorrhage (PPH) in vaginal and cesarean deliveries in a tertiary hospital in Taiwan. Materials and methods: Eligible gravid women (27–41 weeks) with available data were categorized into those treated prophylactically with and without carbetocin. The primary outcome was blood loss and incidence of primary PPH as measured by intrapartum/intraoperative and postpartum (recovery room) blood loss. Results: A total of 1069 deliveries were evaluated. Maternal age (∼31 years of age), body mass index (∼27 kg/m2) and parity (∼1.4) were similar among those treated with and without carbetocin for both vaginal and cesarean deliveries. The majority [749/1069 (70.1%)] of deliveries were vaginal; a similar proportion of women undergoing vaginal [221/749 (29.5%)] and cesarean [110/320 (34.4%)] deliveries received prophylactic carbetocin for prevention of PPH. Among vaginal deliveries, there was no significant difference in intrapartum (p = 0.083) or postpartum (p = 0.925) blood loss, or incidence of PPH (p = 0.092) between women with versus without carbetocin prophylaxis. However, there was a significant reduction in the intraoperative and total blood loss among cesarean deliveries with versus without carbetocin prophylaxis (p < 0.001). The incidence of PPH was higher [84/320 (26.3%)] among cesarean than among vaginal deliveries [62/749 (8.3%)], but was significantly lower among cesarean deliveries with [18 (16.36%)] versus without [66 (30.45%); p = 0.003] carbetocin prophylaxis. Conclusion: In Taiwan, prophylactic use of carbetocin resulted in significantly less blood loss and incidence of PPH in cesarean than in vaginal deliveries.http://www.sciencedirect.com/science/article/pii/S1028455916301917blood losscarbetocincesarean sectionpostpartum hemorrhagevaginal delivery |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chih-Yao Chen Yi-Ning Su Tzu-Hung Lin Yi Chang Huann-Cheng Horng Peng-Hui Wang Chang-Ching Yeh Wen-Hsun Chang Hsin-Yi Huang |
spellingShingle |
Chih-Yao Chen Yi-Ning Su Tzu-Hung Lin Yi Chang Huann-Cheng Horng Peng-Hui Wang Chang-Ching Yeh Wen-Hsun Chang Hsin-Yi Huang Carbetocin in prevention of postpartum hemorrhage: Experience in a tertiary medical center of Taiwan Taiwanese Journal of Obstetrics & Gynecology blood loss carbetocin cesarean section postpartum hemorrhage vaginal delivery |
author_facet |
Chih-Yao Chen Yi-Ning Su Tzu-Hung Lin Yi Chang Huann-Cheng Horng Peng-Hui Wang Chang-Ching Yeh Wen-Hsun Chang Hsin-Yi Huang |
author_sort |
Chih-Yao Chen |
title |
Carbetocin in prevention of postpartum hemorrhage: Experience in a tertiary medical center of Taiwan |
title_short |
Carbetocin in prevention of postpartum hemorrhage: Experience in a tertiary medical center of Taiwan |
title_full |
Carbetocin in prevention of postpartum hemorrhage: Experience in a tertiary medical center of Taiwan |
title_fullStr |
Carbetocin in prevention of postpartum hemorrhage: Experience in a tertiary medical center of Taiwan |
title_full_unstemmed |
Carbetocin in prevention of postpartum hemorrhage: Experience in a tertiary medical center of Taiwan |
title_sort |
carbetocin in prevention of postpartum hemorrhage: experience in a tertiary medical center of taiwan |
publisher |
Elsevier |
series |
Taiwanese Journal of Obstetrics & Gynecology |
issn |
1028-4559 |
publishDate |
2016-12-01 |
description |
Objective: The aim of this retrospective observational study was to determine the efficacy of carbetocin in reducing blood loss and primary postpartum hemorrhage (PPH) in vaginal and cesarean deliveries in a tertiary hospital in Taiwan.
Materials and methods: Eligible gravid women (27–41 weeks) with available data were categorized into those treated prophylactically with and without carbetocin. The primary outcome was blood loss and incidence of primary PPH as measured by intrapartum/intraoperative and postpartum (recovery room) blood loss.
Results: A total of 1069 deliveries were evaluated. Maternal age (∼31 years of age), body mass index (∼27 kg/m2) and parity (∼1.4) were similar among those treated with and without carbetocin for both vaginal and cesarean deliveries. The majority [749/1069 (70.1%)] of deliveries were vaginal; a similar proportion of women undergoing vaginal [221/749 (29.5%)] and cesarean [110/320 (34.4%)] deliveries received prophylactic carbetocin for prevention of PPH. Among vaginal deliveries, there was no significant difference in intrapartum (p = 0.083) or postpartum (p = 0.925) blood loss, or incidence of PPH (p = 0.092) between women with versus without carbetocin prophylaxis. However, there was a significant reduction in the intraoperative and total blood loss among cesarean deliveries with versus without carbetocin prophylaxis (p < 0.001). The incidence of PPH was higher [84/320 (26.3%)] among cesarean than among vaginal deliveries [62/749 (8.3%)], but was significantly lower among cesarean deliveries with [18 (16.36%)] versus without [66 (30.45%); p = 0.003] carbetocin prophylaxis.
Conclusion: In Taiwan, prophylactic use of carbetocin resulted in significantly less blood loss and incidence of PPH in cesarean than in vaginal deliveries. |
topic |
blood loss carbetocin cesarean section postpartum hemorrhage vaginal delivery |
url |
http://www.sciencedirect.com/science/article/pii/S1028455916301917 |
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