Succinate/NLRP3 inflammasome induces synovial fibroblast activation: therapeutical effects of clematichinenoside AR on arthritis

Succinate/NLRP3 inflammasome induces synovial fibroblast activation: therapeutical effects of clematichinenoside AR on arthritis

Clematichinenoside AR (C-AR) is a triterpene saponin isolated from the root of Clematis manshurica Rupr., which is a herbal medicine used in traditional Chinese medicine for the treatment of arthritis. C-AR exerts anti-inflammatory and immunosuppressive properties, but little is known about its acti...

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Bibliographic Details
Main Authors: Yi Li, Jia-Yi Zheng, Jian-Qun Liu, Jie Yang, Yang Liu, Chen Wang, Xiao-Nan Ma, Bao-Lin Liu, Gui-Zhong Xin, Li-Fang Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Immunology
Subjects:
succinate
HIF-1α
collagen-induced arthritis
NLRP3 inflammasome
TGF-β1
Clematichinenoside AR
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00532/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00532/full

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