In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic Pain
Neuropathic pain is a common symptom and is associated with an impaired quality of life. It is caused by the lesion or disease of the somatosensory system. Neuropathic pain syndromes can be subdivided into two categories: central and peripheral neuropathic pain. The present review highlights the per...
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doaj-745313d087914b70add138f6969fbe352020-11-25T02:25:12ZengMDPI AGMolecules1420-30492020-03-01255117110.3390/molecules25051171molecules25051171In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic PainParamita Basu0Arpita Basu1Department of Anesthesiology, Pittsburgh Center for Pain Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USADepartment of Kinesiology and Nutrition Sciences, School of Integrated Health Sciences, University of Nevada, Las Vegas, NV 89154, USANeuropathic pain is a common symptom and is associated with an impaired quality of life. It is caused by the lesion or disease of the somatosensory system. Neuropathic pain syndromes can be subdivided into two categories: central and peripheral neuropathic pain. The present review highlights the peripheral neuropathic models, including spared nerve injury, spinal nerve ligation, partial sciatic nerve injury, diabetes-induced neuropathy, chemotherapy-induced neuropathy, chronic constriction injury, and related conditions. The drugs which are currently used to attenuate peripheral neuropathy, such as antidepressants, anticonvulsants, baclofen, and clonidine, are associated with adverse side effects. These negative side effects necessitate the investigation of alternative therapeutics for treating neuropathic pain conditions. Flavonoids have been reported to alleviate neuropathic pain in murine models. The present review elucidates that several flavonoids attenuate different peripheral neuropathic pain conditions at behavioral, electrophysiological, biochemical and molecular biological levels in different murine models. Therefore, the flavonoids hold future promise and can be effectively used in treating or mitigating peripheral neuropathic conditions. Thus, future studies should focus on the structure-activity relationships among different categories of flavonoids and develop therapeutic products that enhance their antineuropathic effects.https://www.mdpi.com/1420-3049/25/5/1171chemotherapy-induced peripheral neuropathychronic constriction injurydiabetic neuropathydiabetic painful neuropathyflavonoidsoxidative stresspartial sciatic nerve injuryperipheral neuropathyspared nerve injuryspinal nerve ligation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Paramita Basu Arpita Basu |
spellingShingle |
Paramita Basu Arpita Basu In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic Pain Molecules chemotherapy-induced peripheral neuropathy chronic constriction injury diabetic neuropathy diabetic painful neuropathy flavonoids oxidative stress partial sciatic nerve injury peripheral neuropathy spared nerve injury spinal nerve ligation |
author_facet |
Paramita Basu Arpita Basu |
author_sort |
Paramita Basu |
title |
In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic Pain |
title_short |
In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic Pain |
title_full |
In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic Pain |
title_fullStr |
In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic Pain |
title_full_unstemmed |
In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic Pain |
title_sort |
in vitro and in vivo effects of flavonoids on peripheral neuropathic pain |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2020-03-01 |
description |
Neuropathic pain is a common symptom and is associated with an impaired quality of life. It is caused by the lesion or disease of the somatosensory system. Neuropathic pain syndromes can be subdivided into two categories: central and peripheral neuropathic pain. The present review highlights the peripheral neuropathic models, including spared nerve injury, spinal nerve ligation, partial sciatic nerve injury, diabetes-induced neuropathy, chemotherapy-induced neuropathy, chronic constriction injury, and related conditions. The drugs which are currently used to attenuate peripheral neuropathy, such as antidepressants, anticonvulsants, baclofen, and clonidine, are associated with adverse side effects. These negative side effects necessitate the investigation of alternative therapeutics for treating neuropathic pain conditions. Flavonoids have been reported to alleviate neuropathic pain in murine models. The present review elucidates that several flavonoids attenuate different peripheral neuropathic pain conditions at behavioral, electrophysiological, biochemical and molecular biological levels in different murine models. Therefore, the flavonoids hold future promise and can be effectively used in treating or mitigating peripheral neuropathic conditions. Thus, future studies should focus on the structure-activity relationships among different categories of flavonoids and develop therapeutic products that enhance their antineuropathic effects. |
topic |
chemotherapy-induced peripheral neuropathy chronic constriction injury diabetic neuropathy diabetic painful neuropathy flavonoids oxidative stress partial sciatic nerve injury peripheral neuropathy spared nerve injury spinal nerve ligation |
url |
https://www.mdpi.com/1420-3049/25/5/1171 |
work_keys_str_mv |
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