Modulation of dendritic cell immunobiology via inhibition of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase.

Modulation of dendritic cell immunobiology via inhibition of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase.

The maturation status of dendritic cells determines whether interacting T cells are activated or if they become tolerant. Previously we could induce T cell tolerance by applying a 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitor (HMGCRI) atorvastatin, which also modulates MHC class II ex...

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Bibliographic Details
Main Authors: Tina Leuenberger, Caspar F Pfueller, Felix Luessi, Ivo Bendix, Magdalena Paterka, Timour Prozorovski, Denise Treue, Sarah Luenstedt, Josephine Herz, Volker Siffrin, Carmen Infante-Duarte, Frauke Zipp, Sonia Waiczies
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4094470?pdf=render

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http://europepmc.org/articles/PMC4094470?pdf=render

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