Protein quality control of cell stemness
Abstract Protein quality control (PQC) systems play essential roles in the recognition, refolding and clearance of aberrant proteins, thus ensuring cellular protein homeostasis, or proteostasis. Especially, continued proliferation and differentiation of stem cells require a high rate of translation;...
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2020-11-01
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Online Access: | http://link.springer.com/article/10.1186/s13619-020-00064-2 |
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doaj-74cee2d969434776a6d3340e99bc09c92020-11-25T04:09:17ZengSpringerOpenCell Regeneration2045-97692020-11-019111110.1186/s13619-020-00064-2Protein quality control of cell stemnessPengze Yan0Jie Ren1Weiqi Zhang2Jing Qu3Guang-Hui Liu4State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of SciencesUniversity of Chinese Academy of SciencesUniversity of Chinese Academy of SciencesUniversity of Chinese Academy of SciencesState Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of SciencesAbstract Protein quality control (PQC) systems play essential roles in the recognition, refolding and clearance of aberrant proteins, thus ensuring cellular protein homeostasis, or proteostasis. Especially, continued proliferation and differentiation of stem cells require a high rate of translation; therefore, accurate PQC systems are essential to maintain stem cell function. Growing evidence suggested crucial roles of PQC systems in regulating the stemness and differentiation of stem cells. This review focuses on current knowledge regarding the components of the proteostasis network in stem cells, and the importance of proteostasis in maintaining stem cell identity and regenerative functions. A complete understanding of this process might uncover potential applications in aging intervention and aging-related diseases.http://link.springer.com/article/10.1186/s13619-020-00064-2Protein quality controlStem cellsStemnessChaperonesUnfolded protein responseUbiquitin-proteasome system |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pengze Yan Jie Ren Weiqi Zhang Jing Qu Guang-Hui Liu |
spellingShingle |
Pengze Yan Jie Ren Weiqi Zhang Jing Qu Guang-Hui Liu Protein quality control of cell stemness Cell Regeneration Protein quality control Stem cells Stemness Chaperones Unfolded protein response Ubiquitin-proteasome system |
author_facet |
Pengze Yan Jie Ren Weiqi Zhang Jing Qu Guang-Hui Liu |
author_sort |
Pengze Yan |
title |
Protein quality control of cell stemness |
title_short |
Protein quality control of cell stemness |
title_full |
Protein quality control of cell stemness |
title_fullStr |
Protein quality control of cell stemness |
title_full_unstemmed |
Protein quality control of cell stemness |
title_sort |
protein quality control of cell stemness |
publisher |
SpringerOpen |
series |
Cell Regeneration |
issn |
2045-9769 |
publishDate |
2020-11-01 |
description |
Abstract Protein quality control (PQC) systems play essential roles in the recognition, refolding and clearance of aberrant proteins, thus ensuring cellular protein homeostasis, or proteostasis. Especially, continued proliferation and differentiation of stem cells require a high rate of translation; therefore, accurate PQC systems are essential to maintain stem cell function. Growing evidence suggested crucial roles of PQC systems in regulating the stemness and differentiation of stem cells. This review focuses on current knowledge regarding the components of the proteostasis network in stem cells, and the importance of proteostasis in maintaining stem cell identity and regenerative functions. A complete understanding of this process might uncover potential applications in aging intervention and aging-related diseases. |
topic |
Protein quality control Stem cells Stemness Chaperones Unfolded protein response Ubiquitin-proteasome system |
url |
http://link.springer.com/article/10.1186/s13619-020-00064-2 |
work_keys_str_mv |
AT pengzeyan proteinqualitycontrolofcellstemness AT jieren proteinqualitycontrolofcellstemness AT weiqizhang proteinqualitycontrolofcellstemness AT jingqu proteinqualitycontrolofcellstemness AT guanghuiliu proteinqualitycontrolofcellstemness |
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