Electrochemical behaviors and electrochemical determination of carbamazepine at ionic liquid modified carbon paste electrode in the presence of sodium dodecyl sulfate

• Main Authors: Liu Li-Hong, Duan Cheng-Qian, Gao Zuo-Ning
• Format: Article
• Language: English
• Published: Serbian Chemical Society 2012-01-01
• Series: Journal of the Serbian Chemical Society
• Subjects: Carbamazepine; Sodium dodecyl sulfate; Ionic liquid modified carbon paste electrode; Electrochemistry
• Online Access: http://www.doiserbia.nb.rs/img/doi/0352-5139/2012/0352-51391100188L.pdf

The electrochemical behavior and electrochemical determination of carbamazepine (CBZ) at hydrophobic ionic liquid 1-Benzyl-3-Methylimidazole hexafluorophosphate ([BnMIM]PF6) modified carbon paste electrode ([BnMIM]PF6/CPE) in the presence of sodium dodecyl sulfate (SDS) were investigated. A well-defined and sensitive oxidation peak was observed at [BnMIM]PF6/CPE in the presence of SDS and 0.10 M phosphate buffer solution (pH 6.80). The oxidation peak current of CBZ increased significantly at [BnMIM]PF6/CPE in the presence of SDS compared with that in the absence of SDS at carbon paste electrode. It suggested that both SDS and [BnMIM]PF6/CPE show an obvious enhancing effect on the electrochemical oxidation of CBZ. The electrochemical kinetic parameters for CBZ at [BnMIM]PF6/CPE in aqueous SDS solutions were also determined by Chronocoulometry and Chronoamperometry. Finally, the experimental conditions were optimized, and a new electrochemical method of determination for CBZ had been established. The oxidation peak current was linearly dependent on CBZ concentration in the range of 7.0 μM to 0.7 mM with a detection limit of 0.98 μM (signal to noice ratio, S/N = 3). The relative standard deviation for six determinations of 0.10 mM CBZ was between 1.40 and 2.13%. The proposed method was applied in the determination of CBZ in commercial tablet samples.