Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice: genomic analysis of cellular targets.

Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice: genomic analysis of cellular targets.

Patients with non-alcoholic fatty liver disease are characterised by a decreased n-3/n-6 polyunsaturated fatty acid (PUFA) ratio in hepatic phospholipids. The metabolic consequences of n-3 PUFA depletion in the liver are poorly understood. We have reproduced a drastic drop in n-3 PUFA among hepatic...

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Main Authors: Barbara D Pachikian, Ahmed Essaghir, Jean-Baptiste Demoulin, Audrey M Neyrinck, Emilie Catry, Fabienne C De Backer, Nicolas Dejeans, Evelyne M Dewulf, Florence M Sohet, Laurence Portois, Louise Deldicque, Olivier Molendi-Coste, Isabelle A Leclercq, Marc Francaux, Yvon A Carpentier, Fabienne Foufelle, Giulio G Muccioli, Patrice D Cani, Nathalie M Delzenne
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21853118/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21853118/pdf/?tool=EBI

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