Assessing The Effect of Hydro-alcoholic Leaf Extract of Mespilus germanica on the Blood levels of Glucose and Lipids in Streptozotocin Induced Diabetic Male Rats

Background & Objective: Diabetes Mellitus is an abnormality in carbohydrate, lipid and protein metabolism that can lead to hyperglycemia and hyperlipidemia. This study aimed at assessing the effect of hydro-alcoholic leaf extract of Mespilus germanica on the blood levels of glucose and lipids i...

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Main Authors: Marjan Karami, Mokhtar Mokhtari, Esfandiyar Sharifi
Format: Article
Language:fas
Published: Fasa University of Medical Sciences 2014-06-01
Series:Journal of Fasa University of Medical Sciences
Subjects:
rat
Online Access:http://journal.fums.ac.ir/browse.php?a_code=A-10-206-1&slc_lang=en&sid=1
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spelling doaj-756e07af1d9644c8b9bf023cb95adb1a2020-11-24T23:23:22ZfasFasa University of Medical SciencesJournal of Fasa University of Medical Sciences2228-51052228-73292014-06-01418190Assessing The Effect of Hydro-alcoholic Leaf Extract of Mespilus germanica on the Blood levels of Glucose and Lipids in Streptozotocin Induced Diabetic Male RatsMarjan Karami0Mokhtar Mokhtari1Esfandiyar Sharifi2 Department of Biology Islamic Azad University, Kazerun Branch,kazerun, Iran. Department of Biology Islamic Azad University, Kazerun Branch,kazerun, Iran. Department of Biology Islamic Azad University, Kazerun Branch,kazerun, Iran. Background & Objective: Diabetes Mellitus is an abnormality in carbohydrate, lipid and protein metabolism that can lead to hyperglycemia and hyperlipidemia. This study aimed at assessing the effect of hydro-alcoholic leaf extract of Mespilus germanica on the blood levels of glucose and lipids in diabetic male rats. Materials & Methods: In this experimental study 48 adult male rats were randomly divided into six groups of eight. These groups are included: control group which left untreated; sham group which received distilled water; treated control group received only 4000mg/kg leaf extract; diabetic control group receiving only streptozocine; and two diabetic experimental groups of one and two which received 2000 and 4000 mg/kg extract respectively. The extract dosages were administered through gavageing method for sixteen days. Blood samples were taken from all groups and serum levels of glucose and lipids were measured by an auto analyzer. The data were analyzed by SPSS-20 software using ANOVA test. Results: In the experimental groups of 1 and 2, concentration of glucose, triglyceride, total cholesterol and LDL-C decreased significantly in respect to diabetic control group, whereas the serum level of HDL-C showed a significant elevation in these groups. As expected, the levels of glucose, triglyceride, total cholesterol and LDL-C increased significantly in diabetic control group, while, the serum level of HDL-C declined in respect to control group. Conclusion: The results show that the hydro-alcoholic leaf extract of Mespilus germanica may be effective in the treatment of diabetes. This effect can be due to the presence of flavonoieds and their antioxidant features. Keywords: Mespilus germanica, glucose, lipid, rat, diabetes. http://journal.fums.ac.ir/browse.php?a_code=A-10-206-1&slc_lang=en&sid=1Mespilus germanica glucose lipid rat diabetes.
collection DOAJ
language fas
format Article
sources DOAJ
author Marjan Karami
Mokhtar Mokhtari
Esfandiyar Sharifi
spellingShingle Marjan Karami
Mokhtar Mokhtari
Esfandiyar Sharifi
Assessing The Effect of Hydro-alcoholic Leaf Extract of Mespilus germanica on the Blood levels of Glucose and Lipids in Streptozotocin Induced Diabetic Male Rats
Journal of Fasa University of Medical Sciences
Mespilus germanica
glucose
lipid
rat
diabetes.
author_facet Marjan Karami
Mokhtar Mokhtari
Esfandiyar Sharifi
author_sort Marjan Karami
title Assessing The Effect of Hydro-alcoholic Leaf Extract of Mespilus germanica on the Blood levels of Glucose and Lipids in Streptozotocin Induced Diabetic Male Rats
title_short Assessing The Effect of Hydro-alcoholic Leaf Extract of Mespilus germanica on the Blood levels of Glucose and Lipids in Streptozotocin Induced Diabetic Male Rats
title_full Assessing The Effect of Hydro-alcoholic Leaf Extract of Mespilus germanica on the Blood levels of Glucose and Lipids in Streptozotocin Induced Diabetic Male Rats
title_fullStr Assessing The Effect of Hydro-alcoholic Leaf Extract of Mespilus germanica on the Blood levels of Glucose and Lipids in Streptozotocin Induced Diabetic Male Rats
title_full_unstemmed Assessing The Effect of Hydro-alcoholic Leaf Extract of Mespilus germanica on the Blood levels of Glucose and Lipids in Streptozotocin Induced Diabetic Male Rats
title_sort assessing the effect of hydro-alcoholic leaf extract of mespilus germanica on the blood levels of glucose and lipids in streptozotocin induced diabetic male rats
publisher Fasa University of Medical Sciences
series Journal of Fasa University of Medical Sciences
issn 2228-5105
2228-7329
publishDate 2014-06-01
description Background & Objective: Diabetes Mellitus is an abnormality in carbohydrate, lipid and protein metabolism that can lead to hyperglycemia and hyperlipidemia. This study aimed at assessing the effect of hydro-alcoholic leaf extract of Mespilus germanica on the blood levels of glucose and lipids in diabetic male rats. Materials & Methods: In this experimental study 48 adult male rats were randomly divided into six groups of eight. These groups are included: control group which left untreated; sham group which received distilled water; treated control group received only 4000mg/kg leaf extract; diabetic control group receiving only streptozocine; and two diabetic experimental groups of one and two which received 2000 and 4000 mg/kg extract respectively. The extract dosages were administered through gavageing method for sixteen days. Blood samples were taken from all groups and serum levels of glucose and lipids were measured by an auto analyzer. The data were analyzed by SPSS-20 software using ANOVA test. Results: In the experimental groups of 1 and 2, concentration of glucose, triglyceride, total cholesterol and LDL-C decreased significantly in respect to diabetic control group, whereas the serum level of HDL-C showed a significant elevation in these groups. As expected, the levels of glucose, triglyceride, total cholesterol and LDL-C increased significantly in diabetic control group, while, the serum level of HDL-C declined in respect to control group. Conclusion: The results show that the hydro-alcoholic leaf extract of Mespilus germanica may be effective in the treatment of diabetes. This effect can be due to the presence of flavonoieds and their antioxidant features. Keywords: Mespilus germanica, glucose, lipid, rat, diabetes.
topic Mespilus germanica
glucose
lipid
rat
diabetes.
url http://journal.fums.ac.ir/browse.php?a_code=A-10-206-1&slc_lang=en&sid=1
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