Iron Supplementation Interferes With Immune Therapy of Murine Mammary Carcinoma by Inhibiting Anti-Tumor T Cell Function

Iron Supplementation Interferes With Immune Therapy of Murine Mammary Carcinoma by Inhibiting Anti-Tumor T Cell Function

Iron is both, an essential compound for many metabolic processes, and iron deficiency can impact on the proliferation of cells including lymphocytes but also tumor cells. On the other hand, excess iron-catalyzed radical formation can induce cellular toxicity which has been previously demonstrated fo...

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Bibliographic Details
Main Authors: Piotr Tymoszuk, Manfred Nairz, Natascha Brigo, Verena Petzer, Simon Heeke, Brigitte Kircher, Natascha Hermann-Kleiter, Victoria Klepsch, Igor Theurl, Günter Weiss, Christa Pfeifhofer-Obermair
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Oncology
Subjects:
T cell
immunotherapy
cancer prognosis
iron
immune checkpoint
mammary carcinoma
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.584477/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.584477/full

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