CFTR Modulators: The Changing Face of Cystic Fibrosis in the Era of Precision Medicine
Cystic fibrosis (CF) is a lethal inherited disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene, which result in impairment of CFTR mRNA and protein expression, function, stability or a combination of these. Although CF leads to multifaceted clinical manifestations,...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2020-02-01
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Series: | Frontiers in Pharmacology |
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Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2019.01662/full |