Prognostic biomarkers in predicting mortality in respiratory patients with ventilator-associated pneumonia
Abstract Background Ventilator-associated pneumonia (VAP) is the most common nosocomial infection. Red cell distribution width (RDW) and neutrophil-lymphocyte ratio (NLR) are prognostic factors to mortality in different diseases. The aim of this study is to evaluate prognostic efficiency RDW, NLR, a...
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doaj-75e7067bcbe54554ad839e0b94ca06362021-03-21T12:52:21ZengSpringerOpenThe Egyptian Journal of Bronchology1687-84262314-85512021-03-011511810.1186/s43168-021-00062-1Prognostic biomarkers in predicting mortality in respiratory patients with ventilator-associated pneumoniaNermeen A. Abdelaleem0Hoda A. Makhlouf1Eman M. Nagiub2Hassan A. Bayoumi3Department of Chest, Assiut University Hospital, Assiut UniversityDepartment of Chest, Assiut University Hospital, Assiut UniversityDepartment of Clinical Pathology, Assiut University Hospital, Assiut UniversityDepartment of Chest, Assiut University Hospital, Assiut UniversityAbstract Background Ventilator-associated pneumonia (VAP) is the most common nosocomial infection. Red cell distribution width (RDW) and neutrophil-lymphocyte ratio (NLR) are prognostic factors to mortality in different diseases. The aim of this study is to evaluate prognostic efficiency RDW, NLR, and the Sequential Organ Failure Assessment (SOFA) score for mortality prediction in respiratory patients with VAP. Results One hundred thirty-six patients mechanically ventilated and developed VAP were included. Clinical characteristics and SOFA score on the day of admission and at diagnosis of VAP, RDW, and NLR were assessed and correlated to mortality. The average age of patients was 58.80 ± 10.53. These variables had a good diagnostic performance for mortality prediction AUC 0.811 for SOFA at diagnosis of VAP, 0.777 for RDW, 0.728 for NLR, and 0.840 for combined of NLR and RDW. The combination of the three parameters demonstrated excellent diagnostic performance (AUC 0.889). A positive correlation was found between SOFA at diagnosis of VAP and RDW (r = 0.446, P < 0.000) and with NLR (r = 0.220, P < 0.010). Conclusions NLR and RDW are non-specific inflammatory markers that could be calculated quickly and easily via routine hemogram examination. These markers have comparable prognostic accuracy to severity scores. Consequently, RDW and NLR are simple, yet promising markers for ICU physicians in monitoring the clinical course, assessment of organ dysfunction, and predicting mortality in mechanically ventilated patients. Therefore, this study recommends the use of blood biomarkers with the one of the simplest ICU score (SOFA score) in the rapid diagnosis of critical patients as a daily works in ICU.https://doi.org/10.1186/s43168-021-00062-1Red cell distribution width (RDW)Ventilator-associated pneumonia (VAP)MortalityNeutrophil-to-lymphocyte ratio (NLR)Sequential Organ Failure Assessment (SOFA) scoreRespiratory |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nermeen A. Abdelaleem Hoda A. Makhlouf Eman M. Nagiub Hassan A. Bayoumi |
spellingShingle |
Nermeen A. Abdelaleem Hoda A. Makhlouf Eman M. Nagiub Hassan A. Bayoumi Prognostic biomarkers in predicting mortality in respiratory patients with ventilator-associated pneumonia The Egyptian Journal of Bronchology Red cell distribution width (RDW) Ventilator-associated pneumonia (VAP) Mortality Neutrophil-to-lymphocyte ratio (NLR) Sequential Organ Failure Assessment (SOFA) score Respiratory |
author_facet |
Nermeen A. Abdelaleem Hoda A. Makhlouf Eman M. Nagiub Hassan A. Bayoumi |
author_sort |
Nermeen A. Abdelaleem |
title |
Prognostic biomarkers in predicting mortality in respiratory patients with ventilator-associated pneumonia |
title_short |
Prognostic biomarkers in predicting mortality in respiratory patients with ventilator-associated pneumonia |
title_full |
Prognostic biomarkers in predicting mortality in respiratory patients with ventilator-associated pneumonia |
title_fullStr |
Prognostic biomarkers in predicting mortality in respiratory patients with ventilator-associated pneumonia |
title_full_unstemmed |
Prognostic biomarkers in predicting mortality in respiratory patients with ventilator-associated pneumonia |
title_sort |
prognostic biomarkers in predicting mortality in respiratory patients with ventilator-associated pneumonia |
publisher |
SpringerOpen |
series |
The Egyptian Journal of Bronchology |
issn |
1687-8426 2314-8551 |
publishDate |
2021-03-01 |
description |
Abstract Background Ventilator-associated pneumonia (VAP) is the most common nosocomial infection. Red cell distribution width (RDW) and neutrophil-lymphocyte ratio (NLR) are prognostic factors to mortality in different diseases. The aim of this study is to evaluate prognostic efficiency RDW, NLR, and the Sequential Organ Failure Assessment (SOFA) score for mortality prediction in respiratory patients with VAP. Results One hundred thirty-six patients mechanically ventilated and developed VAP were included. Clinical characteristics and SOFA score on the day of admission and at diagnosis of VAP, RDW, and NLR were assessed and correlated to mortality. The average age of patients was 58.80 ± 10.53. These variables had a good diagnostic performance for mortality prediction AUC 0.811 for SOFA at diagnosis of VAP, 0.777 for RDW, 0.728 for NLR, and 0.840 for combined of NLR and RDW. The combination of the three parameters demonstrated excellent diagnostic performance (AUC 0.889). A positive correlation was found between SOFA at diagnosis of VAP and RDW (r = 0.446, P < 0.000) and with NLR (r = 0.220, P < 0.010). Conclusions NLR and RDW are non-specific inflammatory markers that could be calculated quickly and easily via routine hemogram examination. These markers have comparable prognostic accuracy to severity scores. Consequently, RDW and NLR are simple, yet promising markers for ICU physicians in monitoring the clinical course, assessment of organ dysfunction, and predicting mortality in mechanically ventilated patients. Therefore, this study recommends the use of blood biomarkers with the one of the simplest ICU score (SOFA score) in the rapid diagnosis of critical patients as a daily works in ICU. |
topic |
Red cell distribution width (RDW) Ventilator-associated pneumonia (VAP) Mortality Neutrophil-to-lymphocyte ratio (NLR) Sequential Organ Failure Assessment (SOFA) score Respiratory |
url |
https://doi.org/10.1186/s43168-021-00062-1 |
work_keys_str_mv |
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