Functionalization of Gold Nanostars with Cationic β-Cyclodextrin-Based Polymer for Drug Co-Loading and SERS Monitoring

Gold nanostars (AuNSs) exhibit modulated plasmon resonance and have a high SERS enhancement factor. However, their low colloidal stability limits their biomedical application as a nanomaterial. Cationic β-cyclodextrin-based polymer (CCD/P) has low cytotoxicity, can load and transport drugs more effi...

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Main Authors: Orlando Donoso-González, Lucas Lodeiro, Álvaro E. Aliaga, Miguel A. Laguna-Bercero, Soledad Bollo, Marcelo J. Kogan, Nicolás Yutronic, Rodrigo Sierpe
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Pharmaceutics
Subjects:
Online Access:https://www.mdpi.com/1999-4923/13/2/261
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spelling doaj-764c78307ac244d2b18a81f7352445d22021-02-16T00:02:09ZengMDPI AGPharmaceutics1999-49232021-02-011326126110.3390/pharmaceutics13020261Functionalization of Gold Nanostars with Cationic β-Cyclodextrin-Based Polymer for Drug Co-Loading and SERS MonitoringOrlando Donoso-González0Lucas Lodeiro1Álvaro E. Aliaga2Miguel A. Laguna-Bercero3Soledad Bollo4Marcelo J. Kogan5Nicolás Yutronic6Rodrigo Sierpe7Laboratorio de Nanoquímica y Química Supramolecular, Departamento de Química, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, Ñuñoa, 7800003 Santiago, ChileLaboratorio de Química teórica, Departamento de Química, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, Ñuñoa, 7800003 Santiago, ChileLaboratorio de Espectroscopía Vibracional, Departamento de Química, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, Ñuñoa, 7800003 Santiago, ChileInstituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, 50009 Zaragoza, SpainAdvanced Center for Chronic Diseases (ACCDiS), Universidad de Chile and Pontificia Universidad Católica de Chile, 8380000 Santiago, ChileLaboratorio de Nanobiotecnología y Nanotoxicología, Departamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santos Dumont 964, Independencia, 8380000 Santiago, ChileLaboratorio de Nanoquímica y Química Supramolecular, Departamento de Química, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, Ñuñoa, 7800003 Santiago, ChileLaboratorio de Nanoquímica y Química Supramolecular, Departamento de Química, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, Ñuñoa, 7800003 Santiago, ChileGold nanostars (AuNSs) exhibit modulated plasmon resonance and have a high SERS enhancement factor. However, their low colloidal stability limits their biomedical application as a nanomaterial. Cationic β-cyclodextrin-based polymer (CCD/P) has low cytotoxicity, can load and transport drugs more efficiently than the corresponding monomeric form, and has an appropriate cationic group to stabilize gold nanoparticles. In this work, we functionalized AuNSs with CCD/P to load phenylethylamine (PhEA) and piperine (PIP) and evaluated SERS-based applications of the products. PhEA and PIP were included in the polymer and used to functionalize AuNSs, forming a new AuNS-CCD/P-PhEA-PIP nanosystem. The system was characterized by UV–VIS, IR, and NMR spectroscopy, TGA, SPR, DLS, zeta potential analysis, FE-SEM, and TEM. Additionally, Raman optical activity, SERS analysis and complementary theoretical studies were used for characterization. Minor adjustments increased the colloidal stability of AuNSs. The loading capacity of the CCD/P with PhEA-PIP was 95 ± 7%. The physicochemical parameters of the AuNS-CCD/P-PhEA-PIP system, such as size and Z potential, are suitable for potential biomedical applications Raman and SERS studies were used to monitor PhEA and PIP loading and their preferential orientation upon interaction with the surface of AuNSs. This unique nanomaterial could be used for simultaneous drug loading and SERS-based detection.https://www.mdpi.com/1999-4923/13/2/261gold nanostarscationic β-cyclodextrin-based polymerphenylethylaminepiperinedrug co-loadingsurface-enhanced Raman scattering
collection DOAJ
language English
format Article
sources DOAJ
author Orlando Donoso-González
Lucas Lodeiro
Álvaro E. Aliaga
Miguel A. Laguna-Bercero
Soledad Bollo
Marcelo J. Kogan
Nicolás Yutronic
Rodrigo Sierpe
spellingShingle Orlando Donoso-González
Lucas Lodeiro
Álvaro E. Aliaga
Miguel A. Laguna-Bercero
Soledad Bollo
Marcelo J. Kogan
Nicolás Yutronic
Rodrigo Sierpe
Functionalization of Gold Nanostars with Cationic β-Cyclodextrin-Based Polymer for Drug Co-Loading and SERS Monitoring
Pharmaceutics
gold nanostars
cationic β-cyclodextrin-based polymer
phenylethylamine
piperine
drug co-loading
surface-enhanced Raman scattering
author_facet Orlando Donoso-González
Lucas Lodeiro
Álvaro E. Aliaga
Miguel A. Laguna-Bercero
Soledad Bollo
Marcelo J. Kogan
Nicolás Yutronic
Rodrigo Sierpe
author_sort Orlando Donoso-González
title Functionalization of Gold Nanostars with Cationic β-Cyclodextrin-Based Polymer for Drug Co-Loading and SERS Monitoring
title_short Functionalization of Gold Nanostars with Cationic β-Cyclodextrin-Based Polymer for Drug Co-Loading and SERS Monitoring
title_full Functionalization of Gold Nanostars with Cationic β-Cyclodextrin-Based Polymer for Drug Co-Loading and SERS Monitoring
title_fullStr Functionalization of Gold Nanostars with Cationic β-Cyclodextrin-Based Polymer for Drug Co-Loading and SERS Monitoring
title_full_unstemmed Functionalization of Gold Nanostars with Cationic β-Cyclodextrin-Based Polymer for Drug Co-Loading and SERS Monitoring
title_sort functionalization of gold nanostars with cationic β-cyclodextrin-based polymer for drug co-loading and sers monitoring
publisher MDPI AG
series Pharmaceutics
issn 1999-4923
publishDate 2021-02-01
description Gold nanostars (AuNSs) exhibit modulated plasmon resonance and have a high SERS enhancement factor. However, their low colloidal stability limits their biomedical application as a nanomaterial. Cationic β-cyclodextrin-based polymer (CCD/P) has low cytotoxicity, can load and transport drugs more efficiently than the corresponding monomeric form, and has an appropriate cationic group to stabilize gold nanoparticles. In this work, we functionalized AuNSs with CCD/P to load phenylethylamine (PhEA) and piperine (PIP) and evaluated SERS-based applications of the products. PhEA and PIP were included in the polymer and used to functionalize AuNSs, forming a new AuNS-CCD/P-PhEA-PIP nanosystem. The system was characterized by UV–VIS, IR, and NMR spectroscopy, TGA, SPR, DLS, zeta potential analysis, FE-SEM, and TEM. Additionally, Raman optical activity, SERS analysis and complementary theoretical studies were used for characterization. Minor adjustments increased the colloidal stability of AuNSs. The loading capacity of the CCD/P with PhEA-PIP was 95 ± 7%. The physicochemical parameters of the AuNS-CCD/P-PhEA-PIP system, such as size and Z potential, are suitable for potential biomedical applications Raman and SERS studies were used to monitor PhEA and PIP loading and their preferential orientation upon interaction with the surface of AuNSs. This unique nanomaterial could be used for simultaneous drug loading and SERS-based detection.
topic gold nanostars
cationic β-cyclodextrin-based polymer
phenylethylamine
piperine
drug co-loading
surface-enhanced Raman scattering
url https://www.mdpi.com/1999-4923/13/2/261
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