G protein β5-ATM complexes drive acetaminophen-induced hepatotoxicity

G protein β5-ATM complexes drive acetaminophen-induced hepatotoxicity

Excessive ingestion of the common analgesic acetaminophen (APAP) leads to severe hepatotoxicity. Here we identify G protein β5 (Gβ5), elevated in livers from APAP overdose patients, as a critical regulator of cell death pathways and autophagic signaling in APAP-exposed liver. Liver-specific knockdow...

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Bibliographic Details
Main Authors: Arnab Pramanick, Sreemoyee Chakraborti, Tarun Mahata, Madhuri Basak, Kiran Das, Sumit Kumar Verma, Abhishek Singh Sengar, Praveen Kumar Singh, Pranesh Kumar, Bolay Bhattacharya, Sayan Biswas, Parag Baran Pal, Subhasish Sarkar, Vinita Agrawal, Sudipta Saha, Debjani Nath, Suvro Chatterjee, Adele Stewart, Biswanath Maity
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Redox Biology
Subjects:
Acetaminophen
Drug-induced liver injury
G protein β5
ATM
Autophagy
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721001130

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http://www.sciencedirect.com/science/article/pii/S2213231721001130

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